BDBM92863 US9505773, Rapamycin::mTOR Inhibitor, Rapamycin

SMILES CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C/C=C/C=C(C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O

InChI Key InChIKey=QFJCIRLUMZQUOT-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 92863   

LigandPNGBDBM92863(mTOR Inhibitor, Rapamycin | US9505773, Rapamycin)
Affinity DataIC50: 9.60nMAssay Description:The mTOR activity was determined by measuring the amount of [gamma-33 P] phosphae from ATP incorporated in the substrate protein.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM92863(mTOR Inhibitor, Rapamycin | US9505773, Rapamycin)
Affinity DataIC50: 13nMT: 2°CAssay Description:The LanthaScreen TR-FRET mTOR assay was performed using Costar low-binding 284-well plates at room temperature according to the instructions of the m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Isomerase Therapeutics

US Patent
LigandPNGBDBM92863(mTOR Inhibitor, Rapamycin | US9505773, Rapamycin)
Affinity DataKi:  5.40nMAssay Description:The assay was conducted at 10° C. in 50 mM Tris buffer at pH8.0, 50 μM DTT, 100 mM NaCl, 0.005% NP40 with 6 nM FKBP12 and 60 μM substrate (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent