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Found 1018 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [T790M,L858R]'
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200809(US9670231, 2.6)
Affinity DataIC50:  0.0760nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200810(US9670231, 2.7)
Affinity DataIC50:  0.0840nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM199995(US9670231, 1.3 | US9670231, 1.34)
Affinity DataIC50:  0.0880nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM199967(BDBM200762 | US9670231, 1.1)
Affinity DataIC50:  0.100nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200795(US9670231, 1.75)
Affinity DataIC50:  0.180nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200793(US9670231, 1.74)
Affinity DataIC50:  0.200nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200548(US9670231, 1.51)
Affinity DataIC50:  0.210nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200336(US9670231, 1.12)
Affinity DataIC50:  0.210nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200800(US9670231, 2.1)
Affinity DataIC50:  0.25nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM495017(US10994015, Example 313 | US10994015, Example 314)
Affinity DataIC50:  0.290nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200501(US9670231, 1.29)
Affinity DataIC50:  0.300nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM50555575(C-18112003-G | GNS-1480 | GNS1480 | JNJ-73841937-A...)
Affinity DataIC50: <0.300nMAssay Description:WT EGFR and EGFR [L858R/T790M] kinase assay: WT EGFR or EGFR [L858R/T790M] kinase was mixed with different concentrations of pre-diluted compounds fo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM50555575(C-18112003-G | GNS-1480 | GNS1480 | JNJ-73841937-A...)
Affinity DataIC50: <0.300nMAssay Description:WT EGFR and EGFR [L858R/T790M] kinase assay: WT EGFR or EGFR [L858R/T790M] kinase was mixed with different concentrations of pre-diluted compounds fo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM50555575(C-18112003-G | GNS-1480 | GNS1480 | JNJ-73841937-A...)
Affinity DataIC50: <0.300nMAssay Description:WT EGFR and EGFR [L858R/T790M] kinase assay: WT EGFR or EGFR [L858R/T790M] kinase was mixed with different concentrations of pre-diluted compounds fo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM50555575(C-18112003-G | GNS-1480 | GNS1480 | JNJ-73841937-A...)
Affinity DataIC50: <0.300nMAssay Description:WT EGFR and EGFR [L858R/T790M] kinase assay: WT EGFR or EGFR [L858R/T790M] kinase was mixed with different concentrations of pre-diluted compounds fo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200218(US9670231, 1.9)
Affinity DataIC50:  0.300nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM50555575(C-18112003-G | GNS-1480 | GNS1480 | JNJ-73841937-A...)
Affinity DataIC50: <0.300nMAssay Description:WT EGFR and EGFR [L858R/T790M] kinase assay: WT EGFR or EGFR [L858R/T790M] kinase was mixed with different concentrations of pre-diluted compounds fo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM50555575(C-18112003-G | GNS-1480 | GNS1480 | JNJ-73841937-A...)
Affinity DataIC50: <0.300nMAssay Description:WT EGFR and EGFR [L858R/T790M] kinase assay: WT EGFR or EGFR [L858R/T790M] kinase was mixed with different concentrations of pre-diluted compounds fo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200584(US9670231, 1.55)
Affinity DataIC50:  0.400nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200488(US9670231, 1.20)
Affinity DataIC50:  0.420nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM199967(BDBM200762 | US9670231, 1.1)
Affinity DataIC50:  0.460nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200490(US9670231, 1.22)
Affinity DataIC50:  0.470nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200600(US9670231, 1.56)
Affinity DataIC50:  0.470nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200801(US9670231, 2.2)
Affinity DataIC50:  0.490nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM414541(US10435400, Compound Z-54)
Affinity DataIC50:  0.5nMAssay Description:The inhibitory effects of compounds to be tested on double mutant EGFR kinase (EGFR T790M/L858R Kinase) (Invitrogen, PV4879) and wild-type EGFR kinas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200491(US9670231, 1.23)
Affinity DataIC50:  0.520nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200499(US9670231, 1.27)
Affinity DataIC50:  0.540nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM330401((S)—N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro...)
Affinity DataIC50:  0.600nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200478(US9670231, 1.18)
Affinity DataIC50:  0.650nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM495016(US10994015, Example 312)
Affinity DataIC50:  0.670nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200477(US9670231, 1.17)
Affinity DataIC50:  0.760nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM330399(N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro-4-fluoro...)
Affinity DataIC50:  0.800nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM195875(US9670213, Compound 020 N-(3-(2-(4-(4-methyl-1-pip...)
Affinity DataIC50:  0.820nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM200807(US9670231, 2.5)
Affinity DataIC50:  0.820nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM495012(US10994015, Example 308)
Affinity DataIC50:  0.910nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517838(Preparation of N-(5-((4-(benzo[d]thiazol-6-yl)pyri...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517839(Preparation of N-(4-(difluoromethoxy)-2-((2-(dimet...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517840(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517841(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517827(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517845(US11111233, Example 53)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517846(US11111233, Example 54)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517852(Preparation of N-(5-((4-(2-(difluoromethyl)-4-fluo...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517854(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517855(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517856(Preparation of N-(5-((4-(2-(2,2-difluoroethoxy)-4-...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517857(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM517859(Preparation of N-(2-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50: <1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM149409(US10434101, Compound I-9 | US11096942, Compound I-...)
Affinity DataIC50: <1nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM149411(US10434101, Compound I-11 | US11096942, Compound I...)
Affinity DataIC50: <1nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails US Patent
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