2AW1: Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib

PDB ID: 2AW1Download
MMDB ID: 39580
PDB Deposition Date: 2005/8/31
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.46  Å
Source Organism:
Similar Structures:
Biological Unit for 2AW1: monomeric; determined by author
Molecular Components in 2AW1
Label Count Molecule
Protein (1 molecule)
1
Carbonic Anhydrase II
(Gene symbol: CA2)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
ZINC IONZINC ION
2
1
4-(HYDROXYMERCURY)BENZOIC ACID4-(HYDROXYMERCURY)BENZOIC ACID
3
1
4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE
4
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303