2F3F: Crystal Structure Of The Bace Complex With Bdf488, A Macrocyclic Inhibitor

PDB ID: 2F3FDownload
MMDB ID: 40828
PDB Deposition Date: 2005/11/21
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 2F3F: monomeric; determined by author
Molecular Components in 2F3F
Label Count Molecule
Protein (1 molecule)
1
Beta-secretase 1
(Gene symbol: BACE1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2r,4s)-N-Butyl-4-Hydroxy-2-Methyl- 4-((E)-(4as,12r,15s,17as)-15-Methyl -14,17-Dioxo-2,3,4,4a,6,9,11,12,13, 14,15,16,17,17a-Tetradecahydro-1h-5 ,10-Dithia-1,13,16-Triaza-Benzocycl Opentadecen-12-Yl)-Butyramide(2r,4s)-N-Butyl-4-Hydroxy-2-Methyl- 4-((E)-(4as,12r,15s,17as)-15-Methyl -14,17-Dioxo-2,3,4,4a,6,9,11,12,13, 14,15,16,17,17a-Tetradecahydro-1h-5 ,10-Dithia-1,13,16-Triaza-Benzocycl Opentadecen-12-Yl)-Butyramide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303