3HBB: Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate

PDB ID: 3HBBDownload
MMDB ID: 72828
PDB Deposition Date: 2009/5/4
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 3HBB: dimeric; determined by author and by software (PISA)
Molecular Components in 3HBB
Label Count Molecule
Proteins (2 molecules)
2
Dihydrofolate Reductase-thymidylate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
2
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
2
TRIMETREXATETRIMETREXATE
3
14
SULFATE IONSULFATE ION
4
9
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303