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3UM5:
Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP
PDB ID:
3UM5
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MMDB ID:
101312
PDB Deposition Date:
2011/11/12
Updated in MMDB:
2023/11
Experimental Method:
x-ray diffraction
Resolution:
2.4 Å
Source Organism:
Plasmodium falciparum
Similar Structures:
VAST+
Download sequence data
Biological Unit for 3UM5: dimeric; determined by author and by software (PISA)
Molecular Components in 3UM5
Label
Count
Molecule
Proteins (2 molecules)
A
B
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
Chemicals and Non-standard biopolymers (6 molecules)
1
2
5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE
2
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303