4O78: Crystal structure of the first bromodomain of human BRD4 in complex with GW612286X

PDB ID: 4O78Download
MMDB ID: 118090
PDB Deposition Date: 2013/12/24
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.34  Å
Source Organism:
Similar Structures:
Biological Unit for 4O78: monomeric; determined by author and by software (PISA)
Molecular Components in 4O78
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
1
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamineN~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
2
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
4
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303