3U2O: Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor

PDB ID: 3U2ODownload
MMDB ID: 95096
PDB Deposition Date: 2011/10/4
Updated in MMDB: 2011/12
Experimental Method:
x-ray diffraction
Resolution: 2.18  Å
Source Organism:
Similar Structures:
Biological Unit for 3U2O: monomeric; determined by author and by software (PISA)
Molecular Components in 3U2O
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
2
1
OROTIC ACIDOROTIC ACID
3
1
methyl 4-{[(2Z)-2-cyano-3-hydroxypent-2-enoyl]amino}-4'-fluorobiphenyl-2-carboxylatemethyl 4-{[(2Z)-2-cyano-3-hydroxypent-2-enoyl]amino}-4'-fluorobiphenyl-2-carboxylate
4
3
ACETATE IONACETATE ION
5
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303