3S7B: Structural Basis of Substrate Methylation and Inhibition of SMYD2

PDB ID: 3S7BDownload
MMDB ID: 92596
PDB Deposition Date: 2011/5/26
Updated in MMDB: 2011/09
Experimental Method:
x-ray diffraction
Resolution: 2.42  Å
Source Organism:
Similar Structures:
Biological Unit for 3S7B: monomeric; determined by author and by software (PISA)
Molecular Components in 3S7B
Label Count Molecule
Protein (1 molecule)
1
N-lysine Methyltransferase Smyd2
(Gene symbol: SMYD2)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
2
5
(R,R)-2,3-BUTANEDIOL(R,R)-2,3-BUTANEDIOL
3
1
N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamideN-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide
4
3
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303