4K26: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes

PDB ID: 4K26Download
MMDB ID: 119011
PDB Deposition Date: 2013/4/8
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.21  Å
Source Organism:
Similar Structures:
Biological Unit for 4K26: dimeric; determined by author and by software (PISA)
Molecular Components in 4K26
Label Count Molecule
Proteins (2 molecules)
2
Corticosteroid 11-beta-dehydrogenase Isozyme 1
(Gene symbol: Hsd11b1)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
(4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide(4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide
2
3
SULFATE IONSULFATE ION
3
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303