Abstract
3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of P13-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Carbonic Acid / chemistry
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Cell Division / drug effects
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Combinatorial Chemistry Techniques
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Humans
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Imidazoles / chemistry
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Inhibitory Concentration 50
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Mice
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Phosphatidylinositol Phosphates / chemical synthesis
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Phosphatidylinositol Phosphates / pharmacology
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Phosphoinositide-3 Kinase Inhibitors*
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Phospholipid Ethers / chemical synthesis
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Phospholipid Ethers / pharmacology*
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / antagonists & inhibitors
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Proto-Oncogene Proteins c-akt
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Signal Transduction / drug effects
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Imidazoles
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Phosphatidylinositol Phosphates
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Phosphoinositide-3 Kinase Inhibitors
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Phospholipid Ethers
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Proto-Oncogene Proteins
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Carbonic Acid
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AKT1 protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt