Abstract
A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for oral in vivo inhibition.
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Animals
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Cell Division / drug effects
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Drug Design
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology*
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Farnesyltranstransferase
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Kinetics
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Molecular Conformation
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Molecular Structure
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Quinazolines / chemical synthesis*
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Quinazolines / pharmacology*
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Quinolines / chemical synthesis*
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Quinolines / pharmacology*
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Quinolones / chemical synthesis
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Quinolones / pharmacology
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Quinazolines
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Quinolines
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Quinolones
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Alkyl and Aryl Transferases
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Farnesyltranstransferase
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tipifarnib