Abstract
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.
MeSH terms
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Chromatography, High Pressure Liquid
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Neurotransmitter Uptake Inhibitors / chemistry
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Neurotransmitter Uptake Inhibitors / pharmacology*
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Norepinephrine / physiology*
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Quinolines / chemistry*
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Quinolines / pharmacology*
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Structure-Activity Relationship
Substances
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Neurotransmitter Uptake Inhibitors
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Quinolines
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Norepinephrine