Abstract
The synthesis and biological evaluation of some derivatives of pyrazino[1,2-a][1,4]benzodiazepines for anxiolytic and antidepressant activity are presented. Significant levels of anxiolytic activity were noted for 7-(o-chlorophenyl)-9-chloro-1,2,3,4,4a,5-hexahydro-3-methylpyrazino[1,2-a];E11,4]benzodiazepine (4b).
MeSH terms
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Animals
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Anti-Anxiety Agents / chemical synthesis
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Anticonvulsants / chemical synthesis
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Apomorphine / antagonists & inhibitors
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Benzodiazepines / chemical synthesis*
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Benzodiazepines / metabolism
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Benzodiazepines / pharmacology
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Diazepam / metabolism
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Guinea Pigs
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Histamine Antagonists / chemical synthesis
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In Vitro Techniques
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Male
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Norepinephrine / metabolism
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Pyrazines / chemical synthesis
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Pyrazines / pharmacology
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Rats
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Receptors, Drug / metabolism
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Serotonin / metabolism
Substances
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Anti-Anxiety Agents
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Anticonvulsants
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Histamine Antagonists
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Pyrazines
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Receptors, Drug
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Benzodiazepines
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Serotonin
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Apomorphine
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Diazepam
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Norepinephrine