Abstract
A phosphonic acid analogue of S-adenosyl-L-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase, however each presented distinct kinetic characteristics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives
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Adenosine / chemical synthesis*
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Adenosine / pharmacology*
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Adenosylhomocysteinase
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Animals
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Hydrolases / antagonists & inhibitors*
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Kinetics
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Organophosphonates / chemical synthesis*
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Organophosphonates / pharmacology*
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Rats
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Recombinant Proteins
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S-Adenosylhomocysteine / analogs & derivatives*
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S-Adenosylhomocysteine / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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5'-deoxy-5'-((3-amino-3-phosphonopropyl)thio)adenosine
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Enzyme Inhibitors
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Organophosphonates
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Recombinant Proteins
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S-Adenosylhomocysteine
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Hydrolases
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Adenosylhomocysteinase
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Adenosine