Abstract
A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aromatase / chemistry*
-
Aromatase / metabolism
-
Aromatase Inhibitors / chemical synthesis*
-
Aromatase Inhibitors / chemistry
-
Aromatase Inhibitors / metabolism
-
Crystallography, X-Ray
-
Drug Design*
-
Imidazoles / chemical synthesis
-
Imidazoles / chemistry*
-
Imidazoles / metabolism
-
Indoles / chemistry*
-
Molecular Conformation
-
Protein Binding
-
Structure-Activity Relationship
Substances
-
Aromatase Inhibitors
-
Imidazoles
-
Indoles
-
imidazole
-
indole
-
Aromatase