Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering

J Med Chem. 1993 Jul 23;36(15):2235-7. doi: 10.1021/jm00067a022.

Authors

K A Walker¹, D J Kertesz, D M Rotstein, D C Swinney, P W Berry, O Y So, A S Webb, D M Watson, A Y Mak, P M Burton, et al.

Affiliation

¹ Syntex Discovery Research, Palo Alto, California 94304.

PMID: 8340925
DOI: 10.1021/jm00067a022

No abstract available

MeSH terms

Aniline Compounds / chemical synthesis*
Aniline Compounds / pharmacology
Animals
Anticholesteremic Agents / chemical synthesis*
Anticholesteremic Agents / pharmacology
Cholesterol / blood
Cricetinae
Cytochrome P-450 Enzyme Inhibitors*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology
Humans
Oxidoreductases / antagonists & inhibitors*
Rats
Stereoisomerism
Sterol 14-Demethylase
Structure-Activity Relationship
Sulfides / chemical synthesis*
Sulfides / pharmacology

Substances

Aniline Compounds
Anticholesteremic Agents
CYP51A1 protein, human
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Sulfides
azalanstat
Cholesterol
Oxidoreductases
Sterol 14-Demethylase