Abstract
A series of 2-substituted-7-(alkylidene)cephalosporin sulfones were prepared and evaluated as beta-lactamase inhibitors. Compound 11c showed excellent activity as an inhibitor of the class C beta-lactamase derived from Enterobacter cloacae, strain P99.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / pharmacology
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Cephalosporins / chemical synthesis*
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Cephalosporins / pharmacology
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Enterobacter cloacae / drug effects
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Enterobacter cloacae / enzymology
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / enzymology
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Structure-Activity Relationship
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beta-Lactamase Inhibitors*
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beta-Lactamases
Substances
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Alkenes
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Cephalosporins
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Enzyme Inhibitors
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beta-Lactamase Inhibitors
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beta-lactamase PC1
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beta-Lactamases
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beta-lactamase TEM-1