Abstract
N-phenyl-carbamate of D-mannonohydroxymolactone (I) was synthesized from mannose and was shown to be the best competitive inhibitor of beta-mannosidase so far reported (Ki = 25 nM).
MeSH terms
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Hydrogen Bonding
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Mannosidases / antagonists & inhibitors*
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beta-Mannosidase
Substances
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Enzyme Inhibitors
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Mannosidases
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beta-Mannosidase