Abstract
Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(2",6"-O-digalloyl)-beta-D-galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 micrograms/mL, respectively, against HIV-1 integrase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Galactosides / isolation & purification*
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Galactosides / pharmacology
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HIV Integrase Inhibitors / isolation & purification*
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HIV Integrase Inhibitors / pharmacology*
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HIV-1 / enzymology
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Humans
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Korea
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Magnetic Resonance Spectroscopy
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Quercetin / analogs & derivatives*
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Quercetin / isolation & purification
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Quercetin / pharmacology
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
Substances
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Anti-HIV Agents
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Galactosides
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HIV Integrase Inhibitors
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quercetin 3-O-(2'',6''-O-digalloyl)galactopyranoside
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Quercetin