Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

A Chris Krueger; Yibo Xu; Warren M Kati; Dale J Kempf; Clarence J Maring; Keith F McDaniel; Akhteruzzaman Molla; Debra Montgomery; William E Kohlbrenner

doi:10.1016/j.bmcl.2008.01.048

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1692-5. doi: 10.1016/j.bmcl.2008.01.048. Epub 2008 Jan 18.

Authors

A Chris Krueger¹, Yibo Xu, Warren M Kati, Dale J Kempf, Clarence J Maring, Keith F McDaniel, Akhteruzzaman Molla, Debra Montgomery, William E Kohlbrenner

Affiliation

¹ Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, AP-52N, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com

PMID: 18242993
DOI: 10.1016/j.bmcl.2008.01.048

Abstract

The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.

MeSH terms

Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Influenza A virus / drug effects
Influenza B virus / drug effects
Molecular Structure
Neuraminidase / antagonists & inhibitors*
Pyrrolidines / chemistry*
Pyrrolidines / pharmacology*
Structure-Activity Relationship

Substances

Antiviral Agents
Pyrrolidines
Neuraminidase