Flavonoids from Matteuccia struthiopteris and Their Anti-influenza Virus (H1N1) Activity

J Nat Prod. 2015 May 22;78(5):987-95. doi: 10.1021/np500879t. Epub 2015 Apr 30.

Abstract

Seven new flavonoid glycosides (1-7), matteflavosides A-G, together with 12 known flavonoids (8-19) were isolated from the rhizomes of Matteuccia struthiopteris (L.) Todar. Their structures were established via the analyses of extensive spectroscopic data. All compounds were evaluated for their anti-influenza virus (H1N1) activity using the neuraminidase inhibition assay. The results showed that compound 7 exhibited significant inhibitory activity against the H1N1 influenza virus neuraminidase with an EC50 value of 6.8 ± 1.1 μM and an SI value of 34.4, and compounds 8 and 17 showed moderate inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology*
  • China
  • Dogs
  • Ferns / chemistry*
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology*
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Madin Darby Canine Kidney Cells
  • Molecular Structure
  • Neuraminidase / antagonists & inhibitors*
  • Rhizome / chemistry

Substances

  • Antiviral Agents
  • Flavonoids
  • Neuraminidase