Abstract
3,5,6,11-Tetrahydro-2H-imidazo[1',2':1,2]pyrido[3,4-b]indole (10) might be viewed as a fusion structure of two classes of I(2) imidazoline receptor ligands: 2-(2-benzofuranyl)-2-imidazolines and beta-carbolines. Its high affinity (K(i)=7.3 nM) provides insight to how the two classes of agents might bind relative to one another at I(2) receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Imidazoles / chemistry
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Imidazoles / metabolism*
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Imidazoline Receptors
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Indoles / chemistry
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Indoles / metabolism*
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Male
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Protein Binding / physiology
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Pyridones / chemistry
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Pyridones / metabolism
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Rats
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Rats, Wistar
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Receptors, Drug / metabolism*
Substances
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Imidazoles
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Imidazoline Receptors
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Indoles
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Pyridones
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Receptors, Drug
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imidazole