Synthesis and biological activities of NB-506 analogues modified at the glucose group

Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22. doi: 10.1016/s0960-894x(00)00004-4.

Abstract

A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Carbazoles / chemical synthesis*
  • Carbazoles / pharmacology*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Glucose / chemistry
  • Glucosides / chemical synthesis*
  • Glucosides / pharmacology*
  • Humans
  • Indoles*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Stereoisomerism
  • Topoisomerase I Inhibitors*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Carbazoles
  • Enzyme Inhibitors
  • Glucosides
  • Indoles
  • NB 506
  • Topoisomerase I Inhibitors
  • edotecarin
  • Glucose