Abstract
A series of potent PDE5 inhibitors with high selectivity versus PDE6 isoenzymes was identified.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-GMP Phosphodiesterases
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Animals
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Blood Platelets / enzymology
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Cattle
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Cyclic Nucleotide Phosphodiesterases, Type 5
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Cyclic Nucleotide Phosphodiesterases, Type 6
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Molecular Structure
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Phosphodiesterase Inhibitors / chemical synthesis*
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Phosphodiesterase Inhibitors / pharmacology*
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Phosphoric Diester Hydrolases / blood
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Phosphoric Diester Hydrolases / metabolism*
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Pyrazoles / chemical synthesis
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Pyrazoles / pharmacology
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Pyridazines / chemical synthesis*
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Pyridazines / pharmacology*
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Retina / enzymology
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Sensitivity and Specificity
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Structure-Activity Relationship
Substances
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Phosphodiesterase Inhibitors
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Pyrazoles
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Pyridazines
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Phosphoric Diester Hydrolases
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3',5'-Cyclic-GMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 5
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Cyclic Nucleotide Phosphodiesterases, Type 6