Rational approaches to improving selectivity in drug design

J Med Chem. 2012 Feb 23;55(4):1424-44. doi: 10.1021/jm2010332. Epub 2012 Jan 12.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Allosteric Site
  • Drug Design*
  • Models, Molecular*
  • Molecular Conformation
  • Pharmaceutical Preparations / chemistry*
  • Protein Binding
  • Proteins / chemistry*
  • Static Electricity
  • Structure-Activity Relationship
  • Thermodynamics
  • Water / chemistry

Substances

  • Pharmaceutical Preparations
  • Proteins
  • Water