Abstract
The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Carrier Proteins / antagonists & inhibitors*
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins*
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Membrane Transport Proteins*
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Models, Molecular
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Nerve Tissue Proteins*
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Quantitative Structure-Activity Relationship
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins