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  • 6J1O: crystal structure of a sam-dependent methyltransferase lepi from aspergillus flavus (10.1038/S41392-019-0052-Y )
  • 7S0U: prmt5/mep50 crystal structure with mta and phthalazinone fragment bound (10.1021/ACS.JMEDCHEM.1C01900 )
  • 2HTE: the crystal structure of spermidine synthase from p. falciparum in complex with 5'-methylthioadenosine (10.1016/J.MOLBIOPARA.2006.10.011 )
  • 7QBU: b12-dependent radical sam methyltransferase, mmp10 with [4fe-4s] cluster, cobalamin, and s-methyl-5'-thioadenosine bound. (10.1038/S41586-021-04355-9 )
  • 7L1A: human methionine adenosyltransferase 2a bound to methylthioadenosine and inhibitor, di-imido triphosphate (pnpnp) (10.1021/ACS.BIOCHEM.0C00998 )
  • 6VCY: crystal structure of arabidopsis thaliana s-adenosylmethionine synthase 1 (atmat1) in complex with 5'-methylthioadenosine (10.1016/J.IJBIOMAC.2020.02.100 )
  • 6Q2E: crystal structure of methanobrevibacter smithii dph2 bound to 5'- methylthioadenosine (10.1021/ACS.BIOCHEM.9B00718 )
  • 2O05: human spermidine synthase (10.1021/BI602498K )
  • 2O07: human spermidine synthase (10.1021/BI602498K )
  • 2O06: human spermidine synthase (10.1021/BI602498K )
  • 7QBT: b12-dependent radical sam methyltransferase, mmp10 with [4fe-4s] cluster, cobalamin, and s-methyl-5'-thioadenosine bound. (10.1038/S41586-021-04355-9 )
  • 6ZM9: phage sam lyase in complex with s-methyl-5'-thioadenosine (10.7554/ELIFE.61818 )
  • 7UY1: human prmt5:mep50 complex with mta and fragment 5 bound (10.1039/D2MD00163B )
  • 4U0O: crystal structure of thermosynechococcus elongatus lipoyl synthase 2 complexed with mta and dtt (10.1042/BJ20140895 )
  • 7ZUY: human prmt5:mep50 crystal structure with mta and fragment bound (10.1039/D2MD00163B )
  • 7ZUU: human prmt5:mep50 crystal structure with mta and fragment bound (10.1039/D2MD00163B )
  • 5B7P: structures and functional analysis of periplasmic 5- methylthioadenosine/s-adenosylhomocysteine nucleosidase from aeromonas hydrophila (10.1021/ACS.BIOCHEM.7B00691 )
  • 4G41: crystal structure of s-adenosylhomocysteine nucleosidase from streptococcus pyogenes in complex with 5-methylthiotubericidin
  • 2A8Y: crystal structure of 5'-deoxy-5'methylthioadenosine phosphorylase complexed with 5'-deoxy- 5'methylthioadenosine and sulfate (10.1016/J.JMB.2005.12.040 )
  • 4UOE: crystal structure of plasmodium falciparum spermidine synthase in complex with 5'-deoxy-5'-methylioadenosine and 4-aminomethylaniline (10.1107/S1399004714027011 )
  • 3FPF: crystal structure of mtnas in complex with mta and tna (10.1073/PNAS.0904439106 )
  • 8CTB: human prmt5:mep50 structure with fragment 3 and mta bound (10.1039/D2MD00163B )
  • 5F76: crystal structure of mutant s12t of adenosine/methylthioadenosine phosphorylase from schistosoma mansoni in complex with methylthioadenosine (10.1371/JOURNAL.PNTD.0005178 )
  • 6BQ5: crystal structure of medicago truncatula thermospermine synthase (mttsps) in complex with 5'-methylthioadenosine (10.1042/BCJ20170900 )
  • 2YY8: crystal structure of archaeal trna-methylase for position 56 (atrm56) from pyrococcus horikoshii, complexed with s- adenosyl-l-methionine (10.1016/J.JMB.2007.11.023 )
  • 3P2H: crystal structure of tofi in a ternary complex with an inhibitor and mta (10.1073/PNAS.1103165108 )
  • 1CG6: structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with 5'-deoxy-5'-methylthioadenosine and sulfate at 1.7 a resolution (10.1016/S0969-2126(99)80084-7 )
  • 6RR2: crystal structure of nad kinase 1 from listeria monocytogenes in complexe with an adenine derivative (10.1021/ACSINFECDIS.9B00368 )
  • 4CNF: crystal structure of sulfolobus acidocaldarius trmj (10.1261/RNA.044503.114 )
  • 7RXW: human methionine adenosyltransferase 2a bound to methylthioadenosine and inhibitor imido-diphosphate (pnp) (10.1021/JACS.1C09328 )
  • 7RXV: human methionine adenosyltransferase 2a bound to methylthioadenosine, malonate (mla) and mgf3 (10.1021/JACS.1C09328 )
  • 7RXX: human methionine adenosyltransferase 2a bound to methylthioadenosine and two sulfate in the active site (10.1021/JACS.1C09328 )
  • 2E5W: crystal structure of spermidine synthase from pyrococcus horikoshii ot3
  • 5CO4: structural insights into the 2-oh methylation of c/u34 on trna
  • 3T94: crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase (mtap) ii complexed with 5'-deoxy-5'-methylthioadenosine and sulfate (10.1107/S0907444911051699 )
  • 7XIH: crystal structure of the aminopropyltransferase, spee from hyperthermophilic crenarchaeon, pyrobaculum calidifontis in complex with 5'-methylthioadenosine (mta) and spermidine (10.3390/CATAL12050567 )
  • 7XIF: crystal structure of the aminopropyltransferase, spee from hyperthermophilic crenarchaeon, pyrobaculum calidifontis in complex with 5'-methylthioadenosine (mta) alone or together with spermidine or thermospermine (10.3390/CATAL12050567 )
  • 7XIG: crystal structure of the aminopropyltransferase, spee from hyperthermophilic crenarchaeon, pyrobaculum calidifontis in complex with 5'-methylthioadenosine (mta) and spermine (10.3390/CATAL12050567 )
  • 7UYF: human prmt5:mep50 structure with fragment 4 and mta bound (10.1039/D2MD00163B )
  • 5WT3: pyrococcus abyssi methyltransferase patrm5a bound by mta and cognate trna (10.1126/SCIADV.1700195 )
  • 1Z5O: crystal structure of mta/adohcy nucleosidase asp197asn mutant complexed with 5'-methylthioadenosine (10.1016/J.JMB.2005.07.027 )
  • 3KPC: crystal structure of the cbs domain pair of protein mj0100 in complex with 5 -methylthioadenosine and s-adenosyl-l- methionine (10.1016/J.JMB.2009.12.012 )
  • 3V7U: crystal structure of nad kinase 1 from listeria monocytogenes in complex with mta (10.1016/J.STR.2012.03.024 )
  • 7XII: crystal structure of the aminopropyltransferase, spee from hyperthermophilic crenarchaeon, pyrobaculum calidifontis in complex with 5'-methylthioadenosine (mta) & aminopropylagmatine (10.3390/CATAL12050567 )
  • 4BMZ: structure of futalosine hydrolase mutant of helicobacter pylori strain 26695 (10.1107/S1399004713026655 )
  • 4X3L: crystal structure of ttha0275 from thermus thermophilus (hb8) in complex with 5'-methylthioadenosine in space group p21212
  • 3C6M: crystal structure of human spermine synthase in complex with spermine and 5-methylthioadenosine (10.1074/JBC.M710323200 )
  • 3C6K: crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine (10.1074/JBC.M710323200 )
  • 8CSG: human prmt5:mep50 structure with fragment 1 and mta bound (10.1039/D2MD00163B )
  • 5H5D: the crystal structure of the yeast arginine methyltransferase sfm1 complexed with mta (10.1002/1873-3468.12533 )
  • 3B7P: crystal structure of spermidine synthase from plasmodium falciparum in complex with spermine
  • 3ANX: crystal structure of triamine/agmatine aminopropyltransferase (spee) from thermus thermophilus, complexed with mta (10.1016/J.JMB.2011.03.025 )
  • 5HJM: crystal structure of pyrococcus abyssi trm5a complexed with mta (10.1038/SREP33553 )
  • 7ZUP: human prmt5:mep50 structure with fragment (example 18) and mta bound (10.1039/D2MD00163B )
  • 7ZUQ: human prmt5:mep50 crystal structure with mta and fragment bound (10.1039/D2MD00163B )
  • 7UOH: prmt5/mep50 crystal structure with mta and an achiral, class 1, non- atropisomeric inhibitor bound (10.1016/J.BMC.2022.116947 )
  • 1JDT: crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with mta and sulfate ion (10.1074/JBC.M105694200 )
  • 1EG2: crystal structure of rhodobacter spheroides (n6 adenosine) methyltransferase (m.rsri) (10.1093/NAR/28.20.3950 )
  • 4QAT: 1.75 a resolution structure of ct263-d161n (mtan) from chlamydia trachomatis bound to mta (10.1074/JBC.M114.594325 )
  • 6BXM: crystal structure of candidatus methanoperedens nitroreducens dph2 with 4fe-4s cluster and sam/cleaved sam (10.1126/SCIENCE.AAO6595 )
  • 6BXK: crystal structure of pyrococcus horikoshii dph2 with 4fe-4s cluster and mta (10.1126/SCIENCE.AAO6595 )
  • 3A26: crystal structure of p. horikoshii tyw2 in complex with mesado (10.1073/PNAS.0905270106 )
  • 5W8D: the structure of a coa-dependent acyl-homoserine lactone synthase, bjai, with mta (10.1073/PNAS.1705400114 )
  • 5W8C: the structure of a coa-dependent acyl-homoserine lactone synthase, bjai, with mta and isovaleryl-coa (10.1073/PNAS.1705400114 )
  • 4CXM: crystal structure of plasmodium falciparum spermidine synthase in complex with methylthioadenosin and spermidine after catalysis in crystal (10.1107/S1399004714027011 )
  • 3RIE: the structure of plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and n-(3-aminopropyl)-trans-cyclohexane- 1,4-diamine (10.1186/S12936-015-0572-Z )
  • 3KPD: crystal structure of the cbs domain pair of protein mj0100 in complex with 5 -methylthioadenosine and s-adenosyl-l- methionine. (10.1016/J.JMB.2009.12.012 )
  • 4BP1: crystal structure of plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and putrescine (10.1107/S1399004714027011 )
  • 3FUX: t. thermophilus 16s rrna a1518 and a1519 methyltransferase (ksga) in complex with 5'-methylthioadenosine in space group p212121 (10.1016/J.JMB.2009.02.066 )
  • 3FUW: t. thermophilus 16s rrna a1518 and a1519 methyltransferase (ksga) in complex with 5'-methylthioadenosine in space group p212121 (10.1016/J.JMB.2009.02.066 )
  • 5FA5: crystal structure of prmt5:mep50 in complex with mta and h4 peptide (10.1126/SCIENCE.AAD5944 )
  • 6HY1: plasmodium falciparum spermidine synthase in complex with 5'- methylthioadenosine and n,n'-bis(3-aminopropyl)-1,4- cyclohexanediamine after catalysis in crystal
  • 4P54: crystal structure of the helicobacter pylori mtan-d198n mutant with 5'-methylthioadenosine in the active site. (10.1021/BI301221K )
  • 2IPX: human fibrillarin
  • 7SES: prmt5/mep50 with compound 29 bound (10.1021/ACS.JMEDCHEM.1C01900 )
  • 4F0R: crystal structure of an adenosine deaminase homolog from chromobacterium violaceum (target nysgrc-019589) bound zn and 5'- methylthioadenosine (unproductive complex)
  • 6J28: crystal structure of the branched-chain polyamine synthase c9 mutein from thermus thermophilus (tth-bpsa c9) in complex with n4- aminopropylspermidine and 5'-methylthioadenosine (10.1111/FEBS.14949 )
  • 6J26: crystal structure of the branched-chain polyamine synthase from thermococcus kodakarensis (tk-bpsa) in complex with n4- bis(aminopropyl)spermidine and 5'-methylthioadenosine (10.1111/FEBS.14949 )
  • 6J27: crystal structure of the branched-chain polyamine synthase from thermus thermophilus (tth-bpsa) in complex with n4- aminopropylspermidine and 5'-methylthioadenosine (10.1111/FEBS.14949 )
  • 6QMM: crystal structure of synecochoccus spermidine synthase in complex with putrescine, spermidine and mta (10.1042/BCJ20180811 )
  • 5XNC: crystal structure of the branched-chain polyamine synthase (bpsa) in complex with n4-aminopropylspermidine and 5-methylthioadenosine (10.1111/FEBS.14262 )
  • 7C9M: the structure of product-bound cntl, an aminobutyrate transferase in staphylopine biosynthesis (10.1096/FJ.202002287RR )
  • 7S1Q: prmt5/mep50 crystal structure with mta and a phthalazinone inhibitor bound (compound 9) (10.1021/ACS.JMEDCHEM.1C01900 )
  • 7S1S: prmt5/mep50 crystal structure with mta and mrtx-1719 bound (10.1021/ACS.JMEDCHEM.1C01900 )
  • 7S1R: prmt5/mep50 crystal structure with mta and a phthalazinone inhibitor bound (compound (m)-31) (10.1021/ACS.JMEDCHEM.1C01900 )
  • 7ZV2: human prmt5:mep50 crystal structure with mta and fragment bound (10.1039/D2MD00163B )
  • 7ZVL: human prmt5:mep50 crystal structure with mta and fragment bound (10.1039/D2MD00163B )
  • 7ZVU: human prmt5:mep50 crystal structure with mta and fragment bound (10.1039/D2MD00163B )
  • 7SER: prmt5/mep50 with compound 30 bound (10.1021/ACS.JMEDCHEM.1C01900 )
  • 6YMK: crystal structure of the sam-sah riboswitch with amp (10.1093/NAR/GKAA493 )