2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [MePhe7]-Neurokinin B

[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

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[MePhe7]-Neurokinin B Chemical Structure

[MePhe7]-Neurokinin B Chemical Structure

CAS No. : 110880-53-0

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[MePhe7]-Neurokinin B Related Antibodies

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Description

[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R)[1].

IC50 & Target[1]

NK3

3 nM (IC50)

Molecular Weight

1272.49

Formula

C60H81N13O14S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Asp-Met-His-Asp-Phe-Phe-{MePhe}-Gly-Leu-Met-NH2
Sequence Shortening

DMHDFF-{MePhe}-GLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (15.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7859 mL 3.9293 mL 7.8586 mL
5 mM 0.1572 mL 0.7859 mL 1.5717 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7859 mL 3.9293 mL 7.8586 mL 19.6465 mL
5 mM 0.1572 mL 0.7859 mL 1.5717 mL 3.9293 mL
10 mM 0.0786 mL 0.3929 mL 0.7859 mL 1.9647 mL
15 mM 0.0524 mL 0.2620 mL 0.5239 mL 1.3098 mL
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[MePhe7]-Neurokinin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[MePhe7]-Neurokinin B110880-53-0Neurokinin ReceptorNK receptorTachykinin receptorGnRHregulatorsecretionInhibitorinhibitorinhibit

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