2. PI3K/Akt/mTOR
  3. PI3K Akt
  4. PI3K-IN-29

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K.

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PI3K-IN-29 Chemical Structure

PI3K-IN-29 Chemical Structure

CAS No. : 2768005-77-0

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PI3K-IN-29 Related Antibodies

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Description

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

In Vitro

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively[1].
PI3K-IN-29 (U87MG cells; 1, 5 µM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-29 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time: 72 h
Result: Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively.

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 1, 5 µM
Incubation Time: 1 h
Result: Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.
Molecular Weight

560.03

Formula

C27H22ClN7O3S
CAS No.
SMILES

O=S(NC1=CC(C2=CC=C3N=NC=C(C3=C2)C4=CN=C(N=C4)N5CCOCC5)=CN=C1Cl)(C6=CC=CC=C6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3K-IN-29 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-292768005-77-0PI3KAktPhosphoinositide 3-kinasePKBProtein kinase Bantiproliferativecinnoline derivativesPI3K/AktphosphorylationU87MG cellsInhibitorinhibitorinhibit

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