2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. hMC1R agonist 1

(EC50=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family.

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hMC1R agonist 1 Chemical Structure

hMC1R agonist 1 Chemical Structure

CAS No. : 3028881-87-7

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hMC1R agonist 1 Related Antibodies

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Description

(EC50=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for hMC1R over hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), and hMC5R (b>EC50=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family[1].

IC50 & Target

MC1R

 

Molecular Weight

1107.35

Formula

C54H70N14O8S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

metaXylene Ac-{Nle}-Cys-His-{d-Phe}-Arg-Trp-Cys-NH2
Sequence Shortening

metaXylene Ac-{Nle}-CH-{d-Phe}-RWC-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (90.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9031 mL 4.5153 mL 9.0306 mL
5 mM 0.1806 mL 0.9031 mL 1.8061 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9031 mL 4.5153 mL 9.0306 mL 22.5764 mL
5 mM 0.1806 mL 0.9031 mL 1.8061 mL 4.5153 mL
10 mM 0.0903 mL 0.4515 mL 0.9031 mL 2.2576 mL
15 mM 0.0602 mL 0.3010 mL 0.6020 mL 1.5051 mL
20 mM 0.0452 mL 0.2258 mL 0.4515 mL 1.1288 mL
25 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9031 mL
30 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7525 mL
40 mM 0.0226 mL 0.1129 mL 0.2258 mL 0.5644 mL
50 mM 0.0181 mL 0.0903 mL 0.1806 mL 0.4515 mL
60 mM 0.0151 mL 0.0753 mL 0.1505 mL 0.3763 mL
80 mM 0.0113 mL 0.0564 mL 0.1129 mL 0.2822 mL
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hMC1R agonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hMC1R agonist 13028881-87-7Melanocortin ReceptorMC ReceptorselectiveMelanotan-IIpeptideshMC3RhMC4Rmelanocortin familyInhibitorinhibitorinhibit

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