Found 48 with Last Name = 'abad' and Initial = 'jl' TargetNeutral ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Non-competitive inhibition of recombinant ASAH2 stably over expressed in human A-375 cell lysate using RBM14C24 as substrateMore data for this Ligand-Target Pair
TargetNeutral ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Non-competitive inhibition of recombinant ASAH2 stably over expressed in human A-375 cell lysate using RBM14C24 as substrateMore data for this Ligand-Target Pair
TargetNeutral ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataKi: 3.60E+3nMAssay Description:Non-competitive inhibition of recombinant ASAH2 stably over expressed in human A-375 cell lysate using RBM14C24 as substrateMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Rattus norvegicus)
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 5.00E+3nMAssay Description:Competitive inhibition of rat liver microsomal S1PL using varying levels of [3-3H]-D(+) erythro-sphinganine-1-phosphate as substrate incubated for 15...More data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Rattus norvegicus)
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 5.00E+3nMAssay Description:Competitive inhibition of rat S1PL in presence of D(+)-erythro-sphinganine-1-phosphate measured after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetNeutral ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataKi: 5.40E+3nMAssay Description:Non-competitive inhibition of recombinant ASAH2 stably over expressed in human A-375 cell lysate using RBM14C24 as substrateMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 5.60E+3nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 6.30E+3nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 9.10E+3nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 1.64E+4nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 1.75E+4nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 1.90E+4nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 2.04E+4nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAlkaline ceramidase 3(Mus musculus)
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataKi: 2.55E+4nMAssay Description:Non-competitive inhibition of ACER3 in ASAH2-null mouse embryonic fibroblast lysate using RBM14C16 as substrateMore data for this Ligand-Target Pair
TargetAlkaline ceramidase 3(Mus musculus)
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataKi: 3.44E+4nMAssay Description:Non-competitive inhibition of ACER3 in ASAH2-null mouse embryonic fibroblast lysate using RBM14C16 as substrateMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataKi: 3.67E+4nMAssay Description:Competitive inhibition of human S1PL using varying levels of RBM13 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetNeutral ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human ASAH2 using RBM14C24 fluorogenic substrate measured at pH 7.5More data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of human S1PL using RBM13 as substrate measured after 1 hr by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Compound was evaluated for inhibitory activity against 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomesMore data for this Ligand-Target Pair
TargetNeutral ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)
Curated by ChEMBL
Affinity DataIC50: 366nMAssay Description:Inhibition of human ASAH2 stably over expressed in human A-375 cell lysate using RBM14C24 fluorogenic substrate measured at pH 7.5 by fluorescence sp...More data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Rattus norvegicus)
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of rat liver microsomal S1PLMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomesMore data for this Ligand-Target Pair
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetSphingolipid delta(4)-desaturase DES1(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 2.88E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 3.18E+4nMAssay Description:Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.09E+4nMAssay Description:Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomesMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Mus musculus)
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of mouse liver microsomal S1PL using S1P as substrate incubated for 20 mins by ESI-LC/MS analysisMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 8.11E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 8.35E+4nMAssay Description:Compound was evaluated for inhibitory activity against 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomesMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 8.90E+4nMAssay Description:Inhibition of recombinant human S1PL using RBM13 as fluorogenic substrate incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+5nMAssay Description:Compound was evaluated for inhibitory activity against 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomesMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human ASAH1 stably over expressed in human intact A-375 cells using RBM14C12 fluorogenic substrate measured at pH 4.5 by fluorescence s...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human ASAH1 stably over expressed in human intact A-375 cells using RBM14C12 fluorogenic substrate measured at pH 4.5 by fluorescence s...More data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 3.15E+5nMAssay Description:Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysisMore data for this Ligand-Target Pair
TargetAcid ceramidase(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Institute For Advanced Chemistry Of Catalonia
Curated by ChEMBL
Affinity DataIC50: 3.15E+5nMAssay Description:Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysisMore data for this Ligand-Target Pair
