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Found 122 with Last Name = 'aberg' and Initial = 'a'
TargetHistamine H4 receptor(Homo sapiens (Human))
Bridge Pharma

US Patent
LigandPNGBDBM227453(US9333199, S-NORKETOTIFEN (SNORK))
Affinity DataKi:  1.10E+3nMAssay Description:The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Bridge Pharma

US Patent
LigandPNGBDBM181150(US9138431, R-NORKETOTIFEN (RNORK) | US9138431, RS-...)
Affinity DataKi:  2.00E+3nMAssay Description:The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determine...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Bridge Pharma

US Patent
LigandPNGBDBM227454(US9333199, R-NORKETOTIFEN (RNORK))
Affinity DataKi:  2.30E+3nMAssay Description:The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Bridge Pharma

US Patent
LigandPNGBDBM50017674((2-Benzhydryloxy-ethyl)-dimethyl-amine | 2-(benzhy...)
Affinity DataKi:  1.10E+4nMAssay Description:The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determine...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Bridge Pharma

US Patent
LigandPNGBDBM50073179(8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-be...)
Affinity DataKi:  1.60E+4nMAssay Description:The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determine...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H4 receptor(Homo sapiens (Human))
Bridge Pharma

US Patent
LigandPNGBDBM94597((Z)-2-butenedioate;10-(1-methyl-4-piperidinylidene...)
Affinity DataKi:  2.10E+4nMAssay Description:The specific binding of the radioactive ligand to the receptor was defined as the difference between total binding and nonspecific binding, determine...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36395(5-Fluoro-2-thiophen-2-yl-1,2-dihydroquinazolin-4-a...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  15nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  23nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148168((E)-8-Propyl-3,4,5,6,7,8-hexahydro-azocin-2-ylamin...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36396(CD24894148 | N-[2-(4-Amino-5,8-difluoro-1,2-dihydr...)
Affinity DataIC50:  31nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  34nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  35nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36401((2S)-2-Methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  40nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36402((3R)-3-Propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  40nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  45nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM36402((3R)-3-Propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148169((4-Chloro-phenyl)-[4-(4-methoxy-pyridin-2-ylamino)...)
Affinity DataIC50:  53nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50086467((S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-b...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  71nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  74nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36401((2S)-2-Methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  80nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM36401((2S)-2-Methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  80nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148164(4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carbo...)
Affinity DataIC50:  89nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148164(4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carbo...)
Affinity DataIC50:  90nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  98nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36399(CID10221335 | N-[2-(6-Amino-4-methylpyridin-2-yl)e...)
Affinity DataIC50:  120nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  120nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36397((4-Amino-5-fluorospiro[1H-quinazoline-2,4'-pip...)
Affinity DataIC50:  130nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50063300((L-N6-1-iminoethyl)lysine | (S)-6-Acetimidoylamino...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  160nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36402((3R)-3-Propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  200nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148168((E)-8-Propyl-3,4,5,6,7,8-hexahydro-azocin-2-ylamin...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  320nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148162(4-(4-Methyl-pyridin-2-ylamino)-piperidine-1-carbox...)
Affinity DataIC50:  350nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148162(4-(4-Methyl-pyridin-2-ylamino)-piperidine-1-carbox...)
Affinity DataIC50:  350nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36403((3R)-3-(1,2,3,4-Tetrahydroisoquinolin-7-yloxymethy...)
Affinity DataIC50:  400nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148163(CHEMBL112747 | [4-(4-Methoxy-pyridin-2-ylamino)-pi...)
Affinity DataIC50:  530nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM36400(CID24894151 | Ethyl 4-[(4-chloropyridin-2-yl)amino...)
Affinity DataIC50:  720nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  740nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM36399(CID10221335 | N-[2-(6-Amino-4-methylpyridin-2-yl)e...)
Affinity DataIC50:  790nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  790nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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