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Found 125 with Last Name = 'acharya' and Initial = 'kr'
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataKi:  1.20nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataKi:  4.80nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50189452((S)-2-((S)-6-amino-1-((S)-1-carboxy-2-(1H-indol-3-...)
Affinity DataKi:  9nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50010477(CHEMBL1233799)
Affinity DataKi:  11nMAssay Description:Inhibition of human ACE N-terminal domain using Cbz-Phe-His-Leu-OH substrateMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50010479(CHEMBL3264010)
Affinity DataKi:  12nMAssay Description:Inhibition of human ACE N-terminal domain using Cbz-Phe-His-Leu-OH substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50085452((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
Affinity DataKi:  14nMAssay Description:Inhibition of human testis ACE C-domain lacking unique O-glycosylated region, transmembrane anchor and cytoplasmic tail expressed in CHO cells using ...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50010478(CHEMBL3264009)
Affinity DataKi:  21nMAssay Description:Inhibition of human ACE N-terminal domain using Cbz-Phe-His-Leu-OH substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50010478(CHEMBL3264009)
Affinity DataKi:  33nMAssay Description:Inhibition of human ACE C-terminal domain using Cbz-Phe-His-Leu-OH substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583450(CHEMBL5077796)
Affinity DataKi:  35nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50010477(CHEMBL1233799)
Affinity DataKi:  75nMAssay Description:Inhibition of human ACE C-terminal domain using Cbz-Phe-His-Leu-OH substrateMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583449(CHEMBL5075705)
Affinity DataKi:  100nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583450(CHEMBL5077796)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50010479(CHEMBL3264010)
Affinity DataKi:  170nMAssay Description:Inhibition of human ACE C-terminal domain using Cbz-Phe-His-Leu-OH substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50085452((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
Affinity DataKi:  172nMAssay Description:Inhibition of human somatic ACE N-domain soluble form (1 to 629 residues) expressed in CHO cells using Z-FHL as substrate preincubated with enzyme fo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583451(CHEMBL5075686)
Affinity DataKi:  440nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50583450(CHEMBL5077796)
Affinity DataKi:  600nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50189452((S)-2-((S)-6-amino-1-((S)-1-carboxy-2-(1H-indol-3-...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583451(CHEMBL5075686)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50583449(CHEMBL5075705)
Affinity DataKi:  3.79E+3nMAssay Description:Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50527969(CHEMBL4462603)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human testis ACE C-domain lacking unique O-glycosylated region, transmembrane anchor and cytoplasmic tail expressed in CHO cells using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50527969(CHEMBL4462603)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of human somatic ACE N-domain soluble form (1 to 629 residues) expressed in CHO cells using Z-FHL as substrate preincubated with enzyme fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50583449(CHEMBL5075705)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50583451(CHEMBL5075686)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50189452((S)-2-((S)-6-amino-1-((S)-1-carboxy-2-(1H-indol-3-...)
Affinity DataKi: >1.50E+5nMAssay Description:Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307918(2-(5-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307901(5-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hyd...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307899(5-((1H-1,2,4-triazol-1-yl)methyl)biphenyl-2-carbon...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307900(5-((1H-1,2,4-triazol-1-yl)methyl)-4'-hydroxybiphen...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307919(5-((1H-1,2,4-triazol-1-yl)methyl)-3'-chlorobipheny...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307902(5-((1H-1,2,4-triazol-1-yl)methyl)-4'-chloro-3'-hyd...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307881(3'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-(2-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307882(5'-((1H-1,2,4-triazol-1-yl)methyl)-4-chloro-2'-cya...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307883(5'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobipheny...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307916(2-(5-((1H-1,2,4-triazol-1-yl)methyl)biphenyl-3-yl)...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307915(6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hyd...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13061(4,4 -(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitr...)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of steroid sulfatase in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM10015(2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307914(6-((1H-1,2,4-triazol-1-yl)methyl)biphenyl-3-carbon...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307885(2'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-5'-cya...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307886(5'-((1H-1,2,4-triazol-1-yl)methyl)-2'-cyanobipheny...)
Affinity DataIC50:  2nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307887(5'-((1H-1,2,4-triazol-1-yl)methyl)-3-chloro-2'-cya...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307911(4-((1H-1,2,4-triazol-1-yl)methyl)biphenyl-2-carbon...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307884(3-CHLORO-2'-CYANO-5'-(1H-1,2,4-TRIAZOL-1-YLMETHYL)...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of steroid sulfatase in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50307917(2-(5-((1H-1,2,4-triazol-1-yl)methyl)-4'-hydroxybip...)
Affinity DataIC50:  6nMAssay Description:Inhibition of aromatse in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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