Compile Data Set for Download or QSAR
maximum 50k data
Found 905 with Last Name = 'adams' and Initial = 'nd'
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of human Aurora B ATP binding site by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  120nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  490nMAssay Description:Competitive inhibition of human Aurora A ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  492nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316497(CHEMBL1097106 | N-{4-[1-(2,3-Dihydroxypropyl)-4-(1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)
Affinity DataIC50: <1nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316473(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316475(CHEMBL1097191 | N-Ethyl-N'-[4-(1-ethyl-4-{2-[4-(1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316471(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316492(1-(4-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091691(CHEMBL3582356)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316498(CHEMBL1097454 | N-{4-[1-(3-Hydroxypropyl)-4-(1H-py...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316474(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  2.90nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128366(US8802864, 132)
Affinity DataIC50:  3nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316470(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316496(CHEMBL1099010 | N-{4-[1-(2-Hydroxyethyl)-4-(1H-pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316472(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
LigandPNGBDBM50091692(CHEMBL3582357)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316476(CHEMBL1097521 | N'-[4-(1-Ethyl-4-{2-[4-(1-pyrrolid...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Albert Einstein College Of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  4.60nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316479((4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-py...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316478(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128362(US8802864, 42)
Affinity DataIC50:  5nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316477(4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316481(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316483(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM128359(US8802864, 14)
Affinity DataIC50:  6nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataIC50:  6.5nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316482(4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phen...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50316480(4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human Aurora B by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50091689(CHEMBL3582354)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of PI3Kalpha H1047R mutant (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50091696(CHEMBL3582351)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of wild type his-tagged PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM119133((S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cycloprop...)
Affinity DataIC50:  10nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
LigandPNGBDBM50091695(CHEMBL3582350)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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