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Found 1066 with Last Name = 'akashi' and Initial = 'h'
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083552(1,9-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083561(1-{4-[5-amino(imino)methylbenzo[b]thiophen-2-ylcar...)
Affinity DataKi:  0.0280nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083556(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  0.0290nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083541(1-{4-[5-amino(imino)methyl-4,5,6,7-tetrahydrothien...)
Affinity DataKi:  0.0460nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083548(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  0.0570nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217306(CHEMBL112049)
Affinity DataKi:  0.120nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201292(7,8-dichloro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyr...)
Affinity DataKi:  0.120nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201292(7,8-dichloro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyr...)
Affinity DataKi:  0.220nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201280(CHEMBL394137 | {3-[(2-adamantan-1-yl-ethylamino)-m...)
Affinity DataKi:  0.660nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  0.780nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  1nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083549(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098853(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Affinity DataKi:  1.12nMAssay Description:Inhibitory activity against canine skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201280(CHEMBL394137 | {3-[(2-adamantan-1-yl-ethylamino)-m...)
Affinity DataKi:  1.5nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201277((4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][...)
Affinity DataKi:  1.80nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201292(7,8-dichloro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyr...)
Affinity DataKi:  1.80nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201296(4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][1...)
Affinity DataKi:  1.90nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201285(3-((2-cycloheptylethylamino)methyl)-N,N-dimethyl-3...)
Affinity DataKi:  2nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201277((4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][...)
Affinity DataKi:  2.10nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201294(3-((2-cyclopentylethylamino)methyl)-N,N-dimethyl-3...)
Affinity DataKi:  2.40nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201283(3-((2-cyclohexylethylamino)methyl)-N,N-dimethyl-3,...)
Affinity DataKi:  2.5nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098874(4-{2-[5-Amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimid...)
Affinity DataKi:  2.62nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201285(3-((2-cycloheptylethylamino)methyl)-N,N-dimethyl-3...)
Affinity DataKi:  2.70nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201296(4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][1...)
Affinity DataKi:  2.90nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201294(3-((2-cyclopentylethylamino)methyl)-N,N-dimethyl-3...)
Affinity DataKi:  3.30nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098868(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  3.56nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098847(2-(2-{2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyri...)
Affinity DataKi:  3.68nMAssay Description:Inhibitory activity against canine skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201299(7-fluoro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyran-4...)
Affinity DataKi:  4.20nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098853(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Affinity DataKi:  4.85nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201284(3-((cyclohexylmethylamino)methyl)-N,N-dimethyl-3,4...)
Affinity DataKi:  4.90nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201299(7-fluoro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyran-4...)
Affinity DataKi:  5.10nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098854(2-{2-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)...)
Affinity DataKi:  5.57nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098841(2-(2-{2-[5-Amino-2-(3-amino-phenyl)-6-oxo-6H-pyrim...)
Affinity DataKi:  5.60nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50068894(3-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...)
Affinity DataKi:  5.60nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201276(3-((2-(3,6-dihydro-2H-thiopyran-4-yl)ethylamino)me...)
Affinity DataKi:  5.80nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201280(CHEMBL394137 | {3-[(2-adamantan-1-yl-ethylamino)-m...)
Affinity DataKi:  5.90nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201287(CHEMBL435353 | N,N-dimethyl-3-((2-(tetrahydro-2H-p...)
Affinity DataKi:  6nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201283(3-((2-cyclohexylethylamino)methyl)-N,N-dimethyl-3,...)
Affinity DataKi:  6.20nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201286(CHEMBL233201 | N,N-dimethyl-3-((2-(tetrahydro-2H-t...)
Affinity DataKi:  6.80nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201286(CHEMBL233201 | N,N-dimethyl-3-((2-(tetrahydro-2H-t...)
Affinity DataKi:  7.20nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098892(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  7.71nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  8.10nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201291(CHEMBL394255 | N,N-dimethyl-3-((2-(tetrahydropyran...)
Affinity DataKi:  8.80nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098879(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  9.32nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM87059(CHEMBL247767 | Chymostatin)
Affinity DataKi:  9.36nMAssay Description:In vitro inhibitory activity was determined against bovine pancreas chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM87059(CHEMBL247767 | Chymostatin)
Affinity DataKi:  9.36nMAssay Description:inhibitory activity against alpha chymotrypsin from bovine pancreas.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098880(3-{4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl...)
Affinity DataKi:  9.70nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098870(CHEMBL26182 | {4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-py...)
Affinity DataKi:  10.2nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Welfide

Curated by ChEMBL
LigandPNGBDBM50098878(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  10.2nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50201287(CHEMBL435353 | N,N-dimethyl-3-((2-(tetrahydro-2H-p...)
Affinity DataKi:  11nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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