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Found 57 with Last Name = 'akerman' and Initial = 'm'
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183119(4-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183091(4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthal...)
Affinity DataIC50:  18nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183091(4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthal...)
Affinity DataIC50:  31nMAssay Description:Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183102(CHEMBL205279 | N-(4-tert-butylthiazol-2-yl)-1-meth...)
Affinity DataIC50:  37nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183117(4-((diisobutylamino)methyl)-N-(naphthalen-1-yl)thi...)
Affinity DataIC50:  45nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183118(4-tert-butyl-N-(naphthalen-1-yl)thiazol-2-amine | ...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183113(4-tert-butyl-N-(naphthalen-1-yl)oxazol-2-amine | C...)
Affinity DataIC50:  80nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183096(4-isopropyl-N-(naphthalen-1-yl)thiazol-2-amine | C...)
Affinity DataIC50:  170nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183111(4-tert-butyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)...)
Affinity DataIC50:  210nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183100(CHEMBL208458 | N-(4-tert-butylthiazol-2-yl)-1-ethy...)
Affinity DataIC50:  210nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183099(CHEMBL424689 | N-(naphthalen-1-yl)-4-neopentylthia...)
Affinity DataIC50:  220nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183098(4-tert-butyl-N-(2,3-dimethylphenyl)thiazol-2-amine...)
Affinity DataIC50:  260nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183089(CHEMBL207857 | N-(4-tert-butylthiazol-2-yl)quinoli...)
Affinity DataIC50:  300nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183107(6-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50:  340nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183116(3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50:  370nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183095(4-tert-butyl-N-(2-isopropylphenyl)thiazol-2-amine ...)
Affinity DataIC50:  440nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183104(CHEMBL207479 | N-(4-tert-butylthiazol-2-yl)-1H-ind...)
Affinity DataIC50:  490nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183091(4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthal...)
Affinity DataIC50:  530nMAssay Description:Inhibition of TARC-mediated CEM cell migrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183110(4-((diethylamino)methyl)-N-(naphthalen-1-yl)thiazo...)
Affinity DataIC50:  800nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183106(4-(4-tert-butylphenyl)-N-(naphthalen-1-yl)thiazol-...)
Affinity DataIC50:  900nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183109(4-tert-butyl-N-o-tolylthiazol-2-amine | CHEMBL3822...)
Affinity DataIC50:  900nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183088(4-((ethylamino)methyl)-N-(naphthalen-1-yl)thiazol-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183101(CHEMBL378272 | N-(4-tert-butylthiazol-2-yl)isoquin...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183094(4-methyl-N-(naphthalen-1-yl)thiazol-2-amine | CHEM...)
Affinity DataIC50:  1.70E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183114(4-tert-butyl-N-m-tolylthiazol-2-amine | CHEMBL4382...)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183094(4-methyl-N-(naphthalen-1-yl)thiazol-2-amine | CHEM...)
Affinity DataIC50:  3.00E+3nMAssay Description:Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183112(4-tert-butyl-N-phenylthiazol-2-amine | CHEMBL20610...)
Affinity DataIC50:  4.50E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183105(CHEMBL208452 | N-(naphthalen-1-yl)-4-phenylthiazol...)
Affinity DataIC50:  5.50E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183094(4-methyl-N-(naphthalen-1-yl)thiazol-2-amine | CHEM...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of TARC-mediated CEM cell migrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183092(3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50:  1.21E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183108(CHEMBL206039 | N-(4-tert-butylthiazol-2-yl)quinoli...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183090(4-isopropyl-2-(naphthalen-1-ylmethyl)thiazole | CH...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183097(3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183115(CHEMBL207801 | N,4-dimethyl-N-(naphthalen-1-yl)thi...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183093(4-(aminomethyl)-N-(naphthalen-1-yl)thiazol-2-amine...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50183103(4-tert-butyl-N-(naphthalen-1-yl)pyrimidin-2-amine ...)
Affinity DataIC50: >2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362691(CHEMBL1939637)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat GPR40More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362693(CHEMBL1939639)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362694(CHEMBL1939640)
Affinity DataEC50:  580nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362695(CHEMBL1939641)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362696(CHEMBL1939642)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362697(CHEMBL1939643)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362698(CHEMBL1939644)
Affinity DataEC50:  6.70E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362699(CHEMBL1939645)
Affinity DataEC50:  64nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362700(CHEMBL1939646)
Affinity DataEC50:  620nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362701(CHEMBL1939647)
Affinity DataEC50:  6.20E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362702(CHEMBL1939648)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362703(CHEMBL1939649)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362704(CHEMBL1939650)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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