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Found 439 with Last Name = 'alvarez' and Initial = 's'
TargetSphingosine kinase 1(Homo sapiens (Human))
Universidad Nacional De San Luis

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human C-terminal His6-tagged SphK1 expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Universidad Nacional De San Luis

Curated by ChEMBL
LigandPNGBDBM50443389(CHEMBL2376441)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of V5-His-tagged human SphK1 using sphingosine as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Universidad Nacional De San Luis

Curated by ChEMBL
LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of recombinant human GST-tagged SphK1 using [3H]-sphingosine as substrate after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetVitamin D3 receptor(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataIC50:  1.24nMAssay Description:Binding affinity to VDR assessed as inhibition of fluorescent ligand by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14457((+)-4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14461((+)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  1.90nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14473((-)-1-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  2.30nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14467((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14469((-)-4-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  2.60nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14477((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5Hb...)
Affinity DataIC50:  3.10nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14463((+)-4-(3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50: <3.80nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50077853(1-[4-(3,10-Dibromo-8-chloro-5,6-dihydro-benzo[5,6]...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14471((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14471((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14475((-)-1-(3-Bromo-7,8-dichloro-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50570973(CHEMBL4864688)
Affinity DataIC50:  7nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063372(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397221(CHEMBL2172537)
Affinity DataIC50:  15.7nMAssay Description:Binding affinity to VDR assessed as inhibition of fluorescent ligand by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14465((+)-4-(3-Bromo-8-chloro-10-fluoro-6,11-dihydro-5H-...)
Affinity DataIC50:  16.7nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397223(CHEMBL2172539)
Affinity DataIC50:  20.9nMAssay Description:Binding affinity to VDR assessed as inhibition of fluorescent ligand by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459311(CHEMBL1922604 | FR900098)
Affinity DataIC50:  23nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459311(CHEMBL1922604 | FR900098)
Affinity DataIC50:  24nMAssay Description:Inhibition of Plasmodium falciparum DXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063359(1-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50397222(CHEMBL2172538)
Affinity DataIC50:  27.3nMAssay Description:Binding affinity to VDR assessed as inhibition of fluorescent ligand by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50570974(CHEMBL4846069)
Affinity DataIC50:  32nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14466((-)-4-(3-Bromo-8-chloro-10-fluoro-6,11-dihydro-5H-...)
Affinity DataIC50:  33.1nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50:  34nMAssay Description:Inhibition of Plasmodium falciparum DXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063412(4-{2-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benz...)
Affinity DataIC50:  43nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50570974(CHEMBL4846069)
Affinity DataIC50:  44nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14456(4-N-carboxamidopiperidinylacetyl 2 | 4-[2-(4-{6-br...)
Affinity DataIC50:  49nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063379(1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  52nMAssay Description:Inhibition of Farnesyl protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14470((+)-4-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50:  64nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14472((+)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5H-...)
Affinity DataIC50:  78nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14476(3-bromo-8-chloro-7-fluoro-11-{4-[(1-oxidopyridin-4...)
Affinity DataIC50:  86nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14458((-)-4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo...)
Affinity DataIC50: >88nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14455(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)
Affinity DataIC50:  90nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459310(CHEMBL4207168)
Affinity DataIC50:  92nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14468((-)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50: >94nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14460((-)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataIC50: >94nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14462((-)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50: >95nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14474((+)-1-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)
Affinity DataIC50: >99nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14464((-)-4-(3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo...)
Affinity DataIC50: >110nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063453(1-[4-((S)-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclo...)
Affinity DataIC50:  140nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50570973(CHEMBL4864688)
Affinity DataIC50:  155nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50445564(CHEMBL3103256)
Affinity DataIC50:  206nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14454(1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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