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Found 528 with Last Name = 'andersen' and Initial = 'j'
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122077(CHEMBL153017 | N-[1-[5-(6-Amino-hexylamino)-pentyl...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163646(Montbretin A (MbA))
Affinity DataKi:  8.10nM ΔG°:  -47.0kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163647(MbA-G (1))
Affinity DataKi:  9.10nM ΔG°:  -46.7kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201794(CHEMBL3897445)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Handerson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163648(MbA-R (2))
Affinity DataKi:  21.3nM ΔG°:  -44.5kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of recombinant human cathepsin K expressed in Pichia pastoris using Z-FR-MCA as substrate by Dixon plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557298(CHEMBL4750927)
Affinity DataKi:  30nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122093(CHEMBL152879 | N-[1-[4-(7-Amino-heptylamino)-butyl...)
Affinity DataKi:  38nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557293(CHEMBL4781637)
Affinity DataKi:  40nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201793(CHEMBL3899320)
Affinity DataKi:  41nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Handerson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324701(CHEMBL1221472 | Exiguamine A)
Affinity DataKi:  41nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM21975((4S)-16'-(2-aminoethyl)-9'-hydroxy-1,3,6',6'-tetra...)
Affinity DataKi:  41nM ΔG°:  -43.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163649(MbA-RX (3))
Affinity DataKi:  42.4nM ΔG°:  -42.8kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122084(CHEMBL153996 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  64nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122090(CHEMBL147182 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  65nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122096(CHEMBL152410 | Hexanoic acid [1-[8-(3-amino-propyl...)
Affinity DataKi:  68nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122087(CHEMBL153995 | Cyclohexanecarboxylic acid [1-[8-(3...)
Affinity DataKi:  78nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163650(MbA-GR (4))
Affinity DataKi:  79.3nM ΔG°:  -41.2kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324699(CHEMBL1221473 | Seco-exiguamine)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324700(CHEMBL1221412 | Exiguamine B)
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122085(CHEMBL152425 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  88nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122086(CHEMBL269192 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  90nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM163651(MbA-GRX (5) | mini-MbA)
Affinity DataKi:  93.3nM ΔG°:  -40.8kJ/moleT: 2°CAssay Description:Inhibitor concentrations varied from 0.25 to 5 times the Ki value in 50 mM sodium phosphate, 100 mM sodium chloride buffer, pH 7.0, at 30 °C. 2-Chlor...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]cytisine from alpha4/beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122095(CHEMBL355977 | N-[8-(3-Amino-propylamino)-octyl]-3...)
Affinity DataKi:  100nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201793(CHEMBL3899320)
Affinity DataKi:  105nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201793(CHEMBL3899320)
Affinity DataKi:  105nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122091(CHEMBL152736 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  110nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122092(CHEMBL350228 | N-[8-(3-Amino-propylamino)-octyl]-3...)
Affinity DataKi:  110nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50241709(CHEMBL465020 | annulin B)
Affinity DataKi:  120nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122089(CHEMBL352030 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  130nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122094(CHEMBL345521 | Pyridine-2-carboxylic acid [1-[8-(3...)
Affinity DataKi:  130nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122093(CHEMBL152879 | N-[1-[4-(7-Amino-heptylamino)-butyl...)
Affinity DataKi:  135nMAssay Description:Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50241707(CHEMBL518688 | annulin C | methyl 7-ethyl-8-hydrox...)
Affinity DataKi:  140nMAssay Description:Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122086(CHEMBL269192 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  140nMAssay Description:Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50201795(CHEMBL3972383)
Affinity DataKi:  163nMAssay Description:Competitive inhibition of human recombinant cathepsin K using Z-FR-MCA fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122078(CHEMBL422515 | N-[1-[7-(4-Amino-butylamino)-heptyl...)
Affinity DataKi:  168nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557299(CHEMBL4799812)
Affinity DataKi:  170nMAssay Description:Binding affinity to syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122091(CHEMBL152736 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  170nMAssay Description:Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122094(CHEMBL345521 | Pyridine-2-carboxylic acid [1-[8-(3...)
Affinity DataKi:  170nMAssay Description:Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557299(CHEMBL4799812)
Affinity DataKi:  190nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM21979(4,7-dihydro-1H-indole-4,7-dione | Indolequinone, 1...)
Affinity DataKi:  190nM ΔG°:  -39.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM21982(3-(2-aminoethyl)-5-(3-methyl-2,5-dioxo-1-propylimi...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122085(CHEMBL152425 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  210nMAssay Description:Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122081(2-Acetylamino-N-[8-(3-amino-propylamino)-octyl]-3-...)
Affinity DataKi:  220nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122087(CHEMBL153995 | Cyclohexanecarboxylic acid [1-[8-(3...)
Affinity DataKi:  240nMAssay Description:Inhibition of the (-40 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557297(CHEMBL4747962)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557294(CHEMBL4749490)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557295(CHEMBL4758599)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50122083(CHEMBL154012 | N-[1-[8-(3-Amino-propylamino)-octyl...)
Affinity DataKi:  250nMAssay Description:Inhibition of the (-80 mV) current elicited by 100 microM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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