TargetDihydrofolate reductase(Homo sapiens (Human))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataKi: 0nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 0.0300nMAssay Description:Competitive inhibition of Candida albicans DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Competitive inhibition of human recombinant DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolateMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 6.90nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 53nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 59nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 76nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 76.9nMAssay Description:Displacement of [3H]diprenorphine from rat delta receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 95nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 109nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 117nMAssay Description:Displacement of [3H]diprenorphine from rat mu receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 637nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 674nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.81E+3nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 2.05E+3nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from rat mu receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from rat mu receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from rat mu receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from rat mu receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]diprenorphine from rat mu receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair