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Found 48 with Last Name = 'dobia?' and Initial = 'j'
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234807(CHEMBL1738733)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130404(CHEMBL3633687)
Affinity DataIC50:  8nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of human CLK1 (148 to 484 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by AFRREWSPGKEAKK substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005215(CHEMBL3109274)
Affinity DataIC50:  15nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM5875(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234808(CHEMBL4090007)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CLK1 (148 to 484 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by AFRREWSPGKEAKK substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234809(CHEMBL4103030)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CLK1 using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM5875(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM5875(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of VEGFR2 (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50234811(CHEMBL4086603)
Affinity DataIC50:  23nMAssay Description:Inhibition of VEGFR2 (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human CLK3 (275 to 632 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by substrate addition by pyr...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234812(CHEMBL4078755)
Affinity DataIC50:  30nMAssay Description:Inhibition of human CLK1 using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  31nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234807(CHEMBL1738733)
Affinity DataIC50:  37nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  39nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234810(CHEMBL4065167)
Affinity DataIC50:  40nMAssay Description:Inhibition of human CLK1 using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130405(CHEMBL3633688)
Affinity DataIC50:  45nMAssay Description:Inhibition of His6-tagged KDR 789 to 1354 residues (unknown origin) using biotin-Ahx-AEEEYFFLA-amide substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130403(CHEMBL3633689)
Affinity DataIC50:  49nMAssay Description:Inhibition of GST-tagged human KDR expressed in Sf21 cells using 4:1 polyglutamic acid/tyrosine substrate incubated for 15 mins by scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005212(CHEMBL3109275)
Affinity DataIC50:  51nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234808(CHEMBL4090007)
Affinity DataIC50:  55nMAssay Description:Inhibition of human DYRK1A preincubated for 10 mins followed by YRASPSRPESPRPPA-amide substrate addition by pyruvate kinase and lactate dehydrogenase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234811(CHEMBL4086603)
Affinity DataIC50:  80nMAssay Description:Inhibition of human CLK1 using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005213(CHEMBL3109276)
Affinity DataIC50:  170nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  183nMAssay Description:Inhibition of CHK2 (unknown origin) using polypeptide substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234810(CHEMBL4065167)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK9/CyclinT (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50005214(CHEMBL3109277)
Affinity DataIC50:  202nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human GSK3beta using Biotin-labeled GSP-2 peptide substrate after 90 mins in presence of [gamma33-P]ATP by scintillation proximity assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234812(CHEMBL4078755)
Affinity DataIC50:  500nMAssay Description:Inhibition of DYRK1A (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234808(CHEMBL4090007)
Affinity DataIC50:  530nMAssay Description:Inhibition of human CLK3 (275 to 632 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by substrate addition by pyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  725nMAssay Description:Inhibition of CHK1 (unknown origin) using polypeptide substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234809(CHEMBL4103030)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130408(CHEMBL3633692)
Affinity DataIC50:  6.96E+3nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234810(CHEMBL4065167)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50234810(CHEMBL4065167)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of GSK3 alpha/beta (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130410(CHEMBL3633690)
Affinity DataIC50:  4.01E+4nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130406(CHEMBL3633696)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130409(CHEMBL3633691)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50130407(CHEMBL3633695)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataKd:  300nMAssay Description:Binding affinity to full length recombinant human CLK3 (M1 to R490 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to recombinant human CLK4 (R135 to K481 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to recombinant human CLK4 (R135 to K481 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  22nMAssay Description:Binding affinity to full length recombinant human CLK1 (M1 to I484 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  20nMAssay Description:Binding affinity to recombinant human CLK2 (D144 to R498 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  29nMAssay Description:Binding affinity to recombinant human CLK4 (R135 to K481 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to recombinant human CLK2 (D144 to R498 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataKd:  600nMAssay Description:Binding affinity to full length recombinant human CLK1 (M1 to I484 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to full length recombinant human CLK1 (M1 to I484 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Comenius University In Bratislava

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKd:  460nMAssay Description:Binding affinity to recombinant human CLK2 (D144 to R498 residues) expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed