Affinity DataKi: 0.200nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibitory constant aganist Protease-activated receptor 1More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -48.6kJ/molepH: 7.4 T: 2°CAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in rat cortical membrane after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Affinity for Corticotropin releasing factor receptor 1 on IMR-32 (human neuroblastoma) cells by [125I]-sauvagine displacement.More data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Binding affinity towards human muscarinic M1 receptor in CHO-KI cells using [3H]- QNB as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:In vitro inhibitory activity against cloned human M2 muscarinic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.5nM ΔG°: -47.6kJ/molepH: 7.4 T: 2°CAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:In vitro inhibitory activity against cloned human M2 muscarinic receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:Binding affinity towards human muscarinic M1 receptor in CHO-KI cells using [3H]- QNB as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nM ΔG°: -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor transfected in LM(tk-) cell membranes after 120 mins by solid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair