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Found 267 with Last Name = 'downing' and Initial = 'd'
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.5nMAssay Description:Tested for binding affinity towards human D2L receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D3 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.690nMAssay Description:Tested for binding affinity towards human D3 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325237((5S,8S,11S)-11-(2-(3,3-diphenylpropanoyloxy)acetyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325241(CHEMBL1223114)
Affinity DataKi:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.86nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325240(CHEMBL1223113)
Affinity DataKi:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325238((5S,8S,11S)-11-(2-(2-benzyl-3-phenylpropanoyloxy)a...)
Affinity DataKi:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048300(4-(1-[methyl cyclohex-3-en-3-yl phenol]-1,2,3,6-te...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  2.20nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325236((5S,8S,11S)-5-isopropyl-8-methyl-11-(2-(2-(naphtha...)
Affinity DataKi:  3nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  3.30nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048300(4-(1-[methyl cyclohex-3-en-3-yl phenol]-1,2,3,6-te...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D3 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285652((3-{4-[1-((E)-4-{2-[4-(3-Dipropylamino-propoxy)-ph...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048301(4-[1-((R)-3-Phenyl-cyclohex-3-enylmethyl)-1,2,3,6-...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50325239(CHEMBL1223112)
Affinity DataKi:  7nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  7.80nMAssay Description:Tested for binding affinity towards human D3 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285654(CHEMBL87716 | Dibutyl-(3-{4-[1-((E)-4-{2-[4-(3-dib...)
Affinity DataKi:  8nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  8.40nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285656(CHEMBL314663 | Dimeric 2-[4-(3-Aminopropoxy) pheny...)
Affinity DataKi:  9nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285649(CHEMBL86129 | Dimeric 2-[4-(3-Aminopropoxy) phenyl...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048300(4-(1-[methyl cyclohex-3-en-3-yl phenol]-1,2,3,6-te...)
Affinity DataKi:  10.3nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM12197((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  11nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  16.6nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D3 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  17nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  17nMAssay Description:Tested for binding affinity towards human D3 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285650(CHEMBL86249 | Diethyl-[3-(4-{1-[(E)-4-(2-{4-[3-(4-...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  25.5nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  26nMAssay Description:Tested for binding affinity towards human D2L receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285657(CHEMBL315560 | Diethyl-{3-[4-(1-{(E)-4-[2-(4-metho...)
Affinity DataKi:  26nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  28nMAssay Description:Tested for binding affinity towards human D2L receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285644((3-{4-[1-(4-{2-[4-(3-Diethylamino-propoxy)-phenyl]...)
Affinity DataKi:  28nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285655((3-{4-[1-((E)-4-{2-[4-(3-Diethylamino-propoxy)-phe...)
Affinity DataKi:  35nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285648((3-{4-[1-((E)-4-{2-[4-(3-Cyclohexyl-propoxy)-pheny...)
Affinity DataKi:  39nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287527(6-(2-Isopropyl-benzenesulfonyl)-5-nitro-quinolin-8...)
Affinity DataKi:  48nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  53nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285656(CHEMBL314663 | Dimeric 2-[4-(3-Aminopropoxy) pheny...)
Affinity DataKi:  56nMAssay Description:Binding affinity towards human cloned Dopamine D2 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048301(4-[1-((R)-3-Phenyl-cyclohex-3-enylmethyl)-1,2,3,6-...)
Affinity DataKi:  56.7nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D3 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287536(6-(2-Fluoro-benzenesulfonyl)-5-nitro-quinolin-8-yl...)
Affinity DataKi:  58nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  61.4nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D4.2 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048300(4-(1-[methyl cyclohex-3-en-3-yl phenol]-1,2,3,6-te...)
Affinity DataKi:  68nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D4.2 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50285642((3-{4-[1-((E)-4-{2-[4-(3-Diethylamino-propoxy)-phe...)
Affinity DataKi:  87nMAssay Description:Binding affinity towards human cloned Dopamine D3 receptor in CHO cells by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  90.9nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D4.2 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  91nMAssay Description:Tested for binding affinity towards human Dopamine receptor D4.2 using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287529(6-(2-Chloro-benzenesulfonyl)-5-nitro-quinolin-8-yl...)
Affinity DataKi:  93nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048301(4-[1-((R)-3-Phenyl-cyclohex-3-enylmethyl)-1,2,3,6-...)
Affinity DataKi:  94nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287541(5-Nitro-6-(toluene-2-sulfonyl)-quinolin-8-ylamine ...)
Affinity DataKi:  119nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287538(6-(2-Ethyl-benzenesulfonyl)-5-nitro-quinolin-8-yla...)
Affinity DataKi:  129nMAssay Description:Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
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