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Found 134 with Last Name = 'henley' and Initial = 'c'
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414916(CHEMBL567005)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20870(3-{2-[(thiophene-2-sulfonyl)methyl]-1,3-thiazol-4-...)
Affinity DataIC50:  2.10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20851(7-(piperidin-1-ylcarbonyl)-3-[2-(pyridin-4-yl)-1,3...)
Affinity DataIC50:  2.70nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414917(CHEMBL567004)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20856(4-amino-6-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4...)
Affinity DataIC50:  3.80nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414912(CHEMBL566532)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20850(7-[(4-methylpiperazin-1-yl)carbonyl]-3-[2-(pyridin...)
Affinity DataIC50:  4.40nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414918(CHEMBL567832)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20848(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-7-(trifluoro...)
Affinity DataIC50:  6.30nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20849(N-[2-(dimethylamino)ethyl]-N-ethyl-2-oxo-3-[2-(pyr...)
Affinity DataIC50:  8.30nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20869(3-{2-[(pyridine-2-sulfonyl)methyl]-1,3-thiazol-4-y...)
Affinity DataIC50:  10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20847(6-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20855(4-amino-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414898(CHEMBL584268)
Affinity DataIC50:  14nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414914(CHEMBL577495)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20866(3-[2-(4-hydroxyphenyl)-1,3-thiazol-4-yl]-1,2-dihyd...)
Affinity DataIC50:  24nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414900(CHEMBL583636)
Affinity DataIC50:  28nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20868(3-{2-[(benzenesulfonyl)methyl]-1,3-thiazol-4-yl}-1...)
Affinity DataIC50:  29nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20843(methyl 2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414901(CHEMBL567006)
Affinity DataIC50:  36nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414897(CHEMBL566767)
Affinity DataIC50:  47nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20861(3-[2-(pyridin-3-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414904(CHEMBL565471)
Affinity DataIC50:  53nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20842(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM20842(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414899(CHEMBL566114)
Affinity DataIC50:  55nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414903(CHEMBL583632)
Affinity DataIC50:  73nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM20819(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20846(6-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414902(CHEMBL568084)
Affinity DataIC50:  112nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414915(CHEMBL566115)
Affinity DataIC50:  119nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20858(4-amino-6-(4-methylpiperazin-1-yl)-3-[2-(pyridin-4...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20874(3-{2-[(benzenesulfinyl)methyl]-1,3-thiazol-4-yl}-1...)
Affinity DataIC50:  120nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299869(CHEMBL577030 | ethyl 2-methyl-6-oxo-5-(2-(pyridin-...)
Affinity DataIC50:  131nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299869(CHEMBL577030 | ethyl 2-methyl-6-oxo-5-(2-(pyridin-...)
Affinity DataIC50:  131nMAssay Description:Inhibition of human CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414905(CHEMBL565918)
Affinity DataIC50:  139nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414908(CHEMBL566994)
Affinity DataIC50:  157nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414913(CHEMBL578375)
Affinity DataIC50:  160nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20852(4-hydroxy-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,...)
Affinity DataIC50:  160nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20865(3-[2-(4-aminophenyl)-1,3-thiazol-4-yl]-1,2-dihydro...)
Affinity DataIC50:  170nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414907(CHEMBL584506)
Affinity DataIC50:  198nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20871(3-(2-{[(4-chlorobenzene)sulfonyl]methyl}-1,3-thiaz...)
Affinity DataIC50:  240nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20857(4-amino-6-(piperidin-1-yl)-3-[2-(pyridin-4-yl)-1,3...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20872(3-[2-(methanesulfonylmethyl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  300nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20860(3-[2-(thiophen-3-yl)-1,3-thiazol-4-yl]-1,2-dihydro...)
Affinity DataIC50:  410nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20853(4-phenyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  470nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20845(N,N-diethyl-2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-...)
Affinity DataIC50:  480nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414910(CHEMBL567437)
Affinity DataIC50:  647nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414906(CHEMBL567223)
Affinity DataIC50:  672nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50414909(CHEMBL568083)
Affinity DataIC50:  779nMAssay Description:Inhibition of human CDK5/p25 assessed as histone h1 phosphorylation in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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