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Found 336 with Last Name = 'hirst' and Initial = 'wd'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316677(6-Methoxy-8-{4-[1-(8-quinolinyl)-4-piperidinyl]-1-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316673(5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316680(8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]pip...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316684(3,5-Difluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piper...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316688(8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]pip...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316682(6-Bromo-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316690(8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]pip...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316678(8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]pip...)
Affinity DataKi:  0.630nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  0.710nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50130286(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)
Affinity DataKi:  0.760nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316679(3-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin...)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  0.810nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316683(5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin...)
Affinity DataKi:  0.870nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM86708(CAS_146714-97-8 | CHEMBL31354 | CHEMBL514874 | CHE...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50130286(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50130286(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)
Affinity DataKi:  1.02nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Affinity DataKi:  1.05nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316686(8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]pip...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  1.23nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50130268(CHEMBL329383 | N-(2,5-Dibromo-3-fluoro-phenyl)-4-m...)
Affinity DataKi:  1.41nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Affinity DataKi:  1.41nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316685(8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]pip...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM86428(SB-258585)
Affinity DataKi:  1.82nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316681(5-Fluoro-4-methoxy-8-{4-[4-(6-methoxyquinolin-8-yl...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316687(4-Methoxy-8-{4-[4-(6-methoxyquinolin-8-yl)piperazi...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM86427(CAS_50-37-3 | LSD | NSC_3981)
Affinity DataKi:  2.29nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM86428(SB-258585)
Affinity DataKi:  2.29nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50130268(CHEMBL329383 | N-(2,5-Dibromo-3-fluoro-phenyl)-4-m...)
Affinity DataKi:  2.57nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM86427(CAS_50-37-3 | LSD | NSC_3981)
Affinity DataKi:  2.63nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM86427(CAS_50-37-3 | LSD | NSC_3981)
Affinity DataKi:  2.82nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataKi:  2.82nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309848((R)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM31005(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Affinity DataKi:  3.24nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316675(6-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316676(5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataKi:  4.79nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309847((S)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314557((4-(3-(4-(3-nitrophenyl)pyridazino[4,5-b]indolizin...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  6.46nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309845((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309837(1,3'-bipyrrolidin-1'-yl(4-((2-phenyl-1H-benzo[d]im...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  11.0nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(MOUSE)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM86428(SB-258585)
Affinity DataKi:  11.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
Affinity DataKi:  14.4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309851((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-indol-1-yl)meth...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309843((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-methyl-1H...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  21.7nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM82087(2-(5-methoxy-1H-indol-3-yl)ethanamine | 5-MT | 5-M...)
Affinity DataKi:  22.4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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