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Found 138 with Last Name = 'kim' and Initial = 'ji'
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309848((R)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309847((S)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309837(1,3'-bipyrrolidin-1'-yl(4-((2-phenyl-1H-benzo[d]im...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309845((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309851((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-indol-1-yl)meth...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309843((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-methyl-1H...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309834((S)-1,3'-bipyrrolidin-1'-yl(4-((7-chloro-1H-indol-...)
Affinity DataKi:  21.7nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309844(1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazol-1-...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309846((R)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309839((S)-(3-(dimethylamino)pyrrolidin-1-yl)(4-((2-pheny...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309836((3-(ethyl(methyl)amino)pyrrolidin-1-yl)(4-((2-phen...)
Affinity DataKi:  91nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309835((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-phenyl-1H...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309853((S)-1,3'-bipyrrolidin-1'-yl(4-((5-chloro-1H-indol-...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309852((S)-1,3'-bipyrrolidin-1'-yl(4-((6-chloro-1H-indol-...)
Affinity DataKi:  150nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309841((3-(dimethylamino)pyrrolidin-1-yl)(4-((2-(pyridin-...)
Affinity DataKi:  235nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309842((4-((1H-benzo[d]imidazol-1-yl)methyl)phenyl)(3-(di...)
Affinity DataKi:  390nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309849(1,3'-bipyrrolidin-1'-yl(3-((1H-benzo[d]imidazol-1-...)
Affinity DataKi:  400nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309840((R)-(3-(dimethylamino)pyrrolidin-1-yl)(4-((2-pheny...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309838((3-((2-hydroxyethyl)(methyl)amino)pyrrolidin-1-yl)...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50309850(1,3'-bipyrrolidin-1'-yl(2-((1H-benzo[d]imidazol-1-...)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human cloned histamine H3 receptor expressed in HEK293T cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317169((2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime | C...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317171((2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317163((2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime |...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317162((2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime |...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317177(5-nitroindirubin-3'-oxime | CHEMBL369303)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317170((2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime | ...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317164((2'Z,3'E)-5-Trifluoromethoxy-5'-hydroxy-indirubin-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317173((2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime | C...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317167((2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime | ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317166((2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime | ...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM453246(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dih...)
Affinity DataIC50:  12nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK1/cyclin B after 40 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317165((2'Z,3'E)-5-Nitro-5'-chloro-indirubin-3'-oxime | C...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM453265(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dih...)
Affinity DataIC50:  26nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM453264(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dih...)
Affinity DataIC50:  33nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM453265(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dih...)
Affinity DataIC50:  36nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM453246(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dih...)
Affinity DataIC50:  37nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM453228(US10729691, Example 13)
Affinity DataIC50:  47nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM453264(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-7,8-dih...)
Affinity DataIC50:  48nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50514308(CHEMBL4448899)
Affinity DataIC50:  50nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50538375(CHEMBL4633651)
Affinity DataIC50:  58nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317172((2'Z,3'E)-5-Trifluoromethoxy-5'-fluoro-indirubin-3...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM453227(US10729691, Example 12)
Affinity DataIC50:  68nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50538383(CHEMBL4645036)
Affinity DataIC50:  72nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317168((2'Z,3'E)-5-Trifluoromethoxy-5'-chloro-indirubin-3...)
Affinity DataIC50:  76nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM453217(2-(3-(4-((4-(1H-pyrazol-4-yl)phenyl)amino)-5,7-dih...)
Affinity DataIC50:  97nMAssay Description:Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM453228(US10729691, Example 13)
Affinity DataIC50:  102nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50538382(CHEMBL4649311)
Affinity DataIC50:  105nMAssay Description:Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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