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Found 87 with Last Name = 'lavrador' and Initial = 'k'
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152456((S)-3-{3-[4-(3-Acetylamino-phenyl)-piperidin-1-yl]...)
Affinity DataKi:  2nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297861(1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-N-...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316921((S)-1-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297850(1-(4-fluorobenzyl)-2-(4-(4-methyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316922((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158497(2-benzo[b]thiophen-3-yl-N-[1-(3,4-dichlorobenzyl)p...)
Affinity DataKi:  360nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158501(CHEMBL224686 | N-[1-(3,4-dichlorobenzyl)pyrrolidin...)
Affinity DataKi:  510nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158498(2-benzo[1,3]dioxol-5-yl-N-[1-(3,4-dichlorobenzyl)p...)
Affinity DataKi:  630nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316932(2-(1-methylpiperidin-3-yl)-1-((tetrahydrofuran-2-y...)
Affinity DataKi:  638nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316930(2-(1-cyclohexylpiperidin-3-yl)-1-(4-fluorobenzyl)-...)
Affinity DataKi:  926nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158502(CHEMBL224519 | N-[1-(3,4-dichlorobenzyl)pyrrolidin...)
Affinity DataKi:  980nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316924(2-((2-(1-cyclohexylpiperidin-3-yl)-1H-benzo[d]imid...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316935(1-(2-ethoxyethyl)-2-(1-methylpiperidin-3-yl)-1H-be...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316931(1-(4-fluorobenzyl)-2-(1-isopropylpiperidin-3-yl)-1...)
Affinity DataKi:  1.37E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316921((S)-1-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158495(CHEMBL224943 | [5-(4-chlorophenyl)furan-2-ylmethyl...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316928(2-(1-cyclohexylpiperidin-3-yl)-1-(4-methoxybenzyl)...)
Affinity DataKi:  1.84E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316922((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316929(2-(1-isopropylpiperidin-3-yl)-1-(4-methoxybenzyl)-...)
Affinity DataKi:  2.65E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316939((R)-1-(2-ethoxyethyl)-2-(1-(tetrahydro-2H-pyran-4-...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316925(2-(1-cyclohexylpiperidin-3-yl)-1-(2-ethoxyethyl)-1...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316923(4-methyl-2-((2-(1-(tetrahydro-2H-pyran-4-yl)piperi...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158496((R)-N-(1-phenethylpyrrolidin-2-ylmethyl)-4-phenylb...)
Affinity DataKi:  3.10E+3nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316940((R)-1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-...)
Affinity DataKi:  3.86E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297861(1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-N-...)
Affinity DataKi:  4.80E+3nMAssay Description:Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158499(CHEMBL225073 | [5-(4-chlorophenyl)-furan-2-ylmethy...)
Affinity DataKi:  5.00E+3nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316937(1-(4-methoxybenzyl)-2-(1-methylpiperidin-3-yl)-1H-...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316936(2-(1-methylpiperidin-3-yl)-1-(2-phenoxyethyl)-1H-b...)
Affinity DataKi:  5.29E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50411328(CHEMBL2096864)
Affinity DataKi:  6.00E+3nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316945((S)-1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-...)
Affinity DataKi:  6.52E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Rattus norvegicus)
Laboratoire De Chimie Bioorganique

LigandPNGBDBM85447(Epoxy analogue, I(a))
Affinity DataKi:  7.00E+3nM ΔG°:  -30.6kJ/mole IC50:  5.00E+4nMpH: 7.5 T: 2°CAssay Description:AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158494((R)-2-benzo[b]thiophen-3-yl-N-[1-(3,4-dichlorobenz...)
Affinity DataKi:  9.80E+3nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158500(CHEMBL224219 | N-(1-(3,4-dichlorobenzyl)pyrrolidin...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158503(CHEMBL224518 | N-(1-phenethylpyrrolidin-3-yl)-2-ph...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158504(CHEMBL387725 | N-(1-benzylpyrrolidin-3-yl)-2-pheny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297850(1-(4-fluorobenzyl)-2-(4-(4-methyl-1H-pyrazol-1-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316941((S)-2-(1-methylpiperidin-3-yl)-1-(pyridin-2-ylmeth...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316943((S)-1-(2-ethoxyethyl)-2-(1-methylpiperidin-3-yl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316944((R)-1-(2-ethoxyethyl)-2-(1-methylpiperidin-3-yl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316926(1-(2-ethoxyethyl)-2-(1-(tetrahydro-2H-pyran-4-yl)p...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316927(1-(4-methoxybenzyl)-2-(1-(tetrahydro-2H-pyran-4-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316933(4-methyl-2-((2-(1-methylpiperidin-3-yl)-1H-benzo[d...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316934(2-(1-methylpiperidin-3-yl)-1-(pyridin-2-ylmethyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316938(1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-1H-b...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50411329(CHEMBL2096865)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to rat MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316942((R)-2-(1-methylpiperidin-3-yl)-1-(pyridin-2-ylmeth...)
Affinity DataKi:  1.03E+4nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-1(Rattus norvegicus)
Umr 6519

Curated by ChEMBL
LigandPNGBDBM50070637(CHEMBL295971 | L-2-amino-4-methoxy-cis-but-3-enoic...)
Affinity DataKi:  5.60E+4nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant S-adenosyl L-Methionine synthetase (alpha-isoform) in rat liverMore data for this Ligand-Target Pair
TargetS-adenosylmethionine synthase isoform type-2(Rattus norvegicus)
Laboratoire De Chimie Bioorganique

LigandPNGBDBM85448(Epoxy analogue, I(b))
Affinity DataKi:  6.10E+4nM ΔG°:  -25.0kJ/mole IC50:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Rattus norvegicus)
Laboratoire De Chimie Bioorganique

LigandPNGBDBM85450(Epithioamino acid analogue, II(a))
Affinity DataKi:  1.00E+5nM ΔG°:  -23.7kJ/mole IC50:  1.40E+5nMpH: 7.5 T: 2°CAssay Description:AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Rattus norvegicus)
Laboratoire De Chimie Bioorganique

LigandPNGBDBM85449(Epoxy analogue, I(c))
Affinity DataKi:  1.05E+5nM ΔG°:  -23.6kJ/mole IC50:  1.10E+5nMpH: 7.5 T: 2°CAssay Description:AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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