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Found 261 with Last Name = 'lindon' and Initial = 'mj'
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKi:  1.72E+4nMAssay Description:Binding affinity to BRD2 BD1 (unknown origin) by fluorescence anisotropy competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKi:  1.72E+4nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by fluorescence anisotropy competition binding assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKi:  1.72E+4nMAssay Description:Binding affinity to BRD3 BD1 (unknown origin) by fluorescence anisotropy competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158012(CHEMBL183351 | N-[13-(5-Chloro-thiophene-2-sulfony...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157998(5-Chloro-thiophene-2-sulfonic acid [5-(2-morpholin...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158017(CHEMBL180384 | N-[13-(5-Chloro-thiophene-2-sulfony...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158000(CHEMBL183774 | N-[13-(5-Chloro-thiophene-2-sulfony...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157983(CHEMBL183558 | N-[13-(5-Chloro-thiophene-2-sulfony...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  10nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526962(CHEMBL4448056)
Affinity DataIC50:  10nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50157994(CHEMBL183764 | Pyridine-2-carboxylic acid [13-(5-c...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526964(CHEMBL4438171)
Affinity DataIC50:  13nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  13nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50158009(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-imida...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158018((13-Benzenesulfonylamino-tricyclo[8.2.1.0*3,8*]tri...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  16nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escheri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50603088(CHEMBL5203965)
Affinity DataIC50:  20nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) incubated for 30 mins in presence of fluorescent ligand by TR-FRET methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(CHEMBL245568 | SB-649701)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157975(5-Chloro-thiophene-2-sulfonic acid {5-[(E)-3-(4-ph...)
Affinity DataIC50:  21nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157966(CHEMBL180784 | [13-(5-Chloro-thiophene-2-sulfonyla...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(CHEMBL245568 | SB-649701)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  25nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/BD2 Y309A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50:  25nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
LigandPNGBDBM50158010(5-Chloro-thiophene-2-sulfonic acid (5-fluoro-tricy...)
Affinity DataIC50:  29nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526959(CHEMBL4522991)
Affinity DataIC50:  31.6nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423251(CHEMBL240461)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526959(CHEMBL4522991)
Affinity DataIC50:  32nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50:  32nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157965(5-Chloro-thiophene-2-sulfonic acid (4-fluoro-tricy...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158008(5-Chloro-thiophene-2-sulfonic acid {5-[(E)-3-(4-me...)
Affinity DataIC50:  39nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423244(CHEMBL397395)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50:  40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escheri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544616(CHEMBL4635329)
Affinity DataIC50:  40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD2 (1 to 473 residues)/BD1 Y113A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526961(CHEMBL4576013)
Affinity DataIC50:  40nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50:  40nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157984(CHEMBL182349 | N-[13-(5-Chloro-thiophene-2-sulfony...)
Affinity DataIC50:  41nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423250(CHEMBL395424)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526950(CHEMBL4547614)
Affinity DataIC50:  50nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataIC50:  50nMAssay Description:Displacement of bromosporine-tracer from BRD4 (unknown origin) expressed in HEK293 cells by NanoBRET NanoGlo substrate based NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50526967(CHEMBL4579229)
Affinity DataIC50:  50nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50157977(CHEMBL183654 | Thiophene-2-sulfonic acid tricyclo[...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50380682(CHEMBL2017291 | I-BET151 (16))
Affinity DataIC50:  50nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escher...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50544603(CHEMBL4633643)
Affinity DataIC50:  50nMAssay Description:Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escher...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50157973(5-chloro-thiophene-2-sulfonic acid tricyclo[8.2.1....)
Affinity DataIC50:  62nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Gsk

Curated by ChEMBL
LigandPNGBDBM50603097(CHEMBL5195288)
Affinity DataIC50:  63nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) incubated for 30 mins in presence of fluorescent ligand by TR-FRET methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
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