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Found 1284 with Last Name = 'lynch' and Initial = 'm'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50073254(Anthranilamide derivative | CHEMBL408110)
Affinity DataKi:  0.0600nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285701(Anthranilamide derivative | CHEMBL313767)
Affinity DataKi:  0.0700nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492970(CHEMBL2415082)
Affinity DataKi:  0.140nMAssay Description:Displacement of Eu-DTPA-PEGO-NDP-alpha-MSH-NH2 from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133232((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133233(1-Methyl-2-(3-methyl-3,7,8,9-tetrahydro-pyrano[3,2...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285698(Anthranilamide derivative | CHEMBL315500)
Affinity DataKi:  0.260nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  0.300nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  0.300nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50274953(5-(3-benzylpyrrolidin-3-yl)-1H-indole-2-carbonitri...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285700(Anthranilamide derivative | CHEMBL315742)
Affinity DataKi:  0.450nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133230((R)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM93624(5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003039(2-(3,7,8,9-Tetrahydro-pyrano[3,2-e]indol-1-yl)-eth...)
Affinity DataKi:  0.600nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50329746(CHEMBL1271731 | endo-2-((3S,5S)-3,5-dimethylmorpho...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50275439(5-(3-benzylpyrrolidin-3-yl)-1H-indazole | CHEMBL52...)
Affinity DataKi:  1nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50274951(5-(3-benzylpyrrolidin-3-yl)-1-methyl-1H-indole | C...)
Affinity DataKi:  1nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50014945(3-(2-aminopropyl)-1H-indol-5-ol | CHEMBL275854 | a...)
Affinity DataKi:  1nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50329748(CHEMBL1271791 | endo-2-((3S,5S)-3-ethyl-5-methylmo...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003037(2-(3-Methyl-3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  1.10nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50066144(CHEMBL3400295)
Affinity DataKi:  1.20nMAssay Description:Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285703(Anthranilamide derivative | CHEMBL315928)
Affinity DataKi:  1.20nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285696(Anthranilamide derivative | CHEMBL85640)
Affinity DataKi:  1.20nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492969(CHEMBL2415084)
Affinity DataKi:  1.5nMAssay Description:Displacement of Eu-DTPA-PEGOMSH(7) from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50014219(2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine | ...)
Affinity DataKi:  1.60nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492971(CHEMBL2415081)
Affinity DataKi:  1.70nMAssay Description:Displacement of Eu-DTPA-PEGOMSH(7) from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492975(CHEMBL2415019)
Affinity DataKi:  1.80nMAssay Description:Displacement of Eu-DTPA-PEGOMSH(7) from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50329745(CHEMBL1271730 | endo-2-((S)-3-tert-butylmorpholino...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50274954(5-(3-benzylpyrrolidin-3-yl)-1H-indole-2-carboxamid...)
Affinity DataKi:  2nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133232((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...)
Affinity DataKi:  2nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285691(Anthranilamide derivative | CHEMBL264622)
Affinity DataKi:  2.40nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492972(CHEMBL2415080)
Affinity DataKi:  2.40nMAssay Description:Displacement of Eu-DTPA-PEGOMSH(7) from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50329724(CHEMBL1271960 | endo-2-((2S,6S)-2,6-dimethylpipera...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133233(1-Methyl-2-(3-methyl-3,7,8,9-tetrahydro-pyrano[3,2...)
Affinity DataKi:  2.70nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285695(Anthranilamide derivative | CHEMBL86263)
Affinity DataKi:  3nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50275440(3-(benzo[b]thiophen-5-yl)-3-benzylpyrrolidine | CH...)
Affinity DataKi:  3nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492970(CHEMBL2415082)
Affinity DataKi:  3.10nMAssay Description:Displacement of Eu-DTPA-PEGOMSH(7) from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50492969(CHEMBL2415084)
Affinity DataKi:  3.40nMAssay Description:Displacement of Eu-DTPA-PEGO-NDP-alpha-MSH-NH2 from human MC4R expressed in HEL293 cells after 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133232((S)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...)
Affinity DataKi:  3.40nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50329744(CHEMBL1271678 | endo-2-((S)-3-isobutylmorpholino)-...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133230((R)-1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]in...)
Affinity DataKi:  3.60nMAssay Description:Inhibitory constant determined against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  3.60nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50066145(CHEMBL3400296)
Affinity DataKi:  3.70nMAssay Description:Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50329742(CHEMBL1271629 | endo-N-((1R,5R)-9-methyl-9-azabicy...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133231((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Affinity DataKi:  4nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50274952(CHEMBL512551 | ethyl 5-(3-benzylpyrrolidin-3-yl)-1...)
Affinity DataKi:  4nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50274951(5-(3-benzylpyrrolidin-3-yl)-1-methyl-1H-indole | C...)
Affinity DataKi:  4nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50003036(CHEMBL412876 | Dimethyl-[2-(3,7,8,9-tetrahydro-pyr...)
Affinity DataKi:  4.10nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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