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Found 386 with Last Name = 'maeda' and Initial = 'dy'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  2.20nMAssay Description:Compound was tested for its binding affinity against sigma 1 opioid receptor using 3[H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  3.10nMAssay Description:Compound was tested for its binding affinity against sigma 1 opioid receptor using 3[H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109385(4-Methyl-1-(3-phenyl-propyl)-piperidine | CHEMBL35...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109384(3-Methyl-1-phenethyl-piperidine | CHEMBL144552)
Affinity DataKi:  4.20nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50084012((3,4-Dichloro-phenyl)-acetic acid 2-pyrrolidin-1-y...)
Affinity DataKi:  4.90nMAssay Description:Compound was tested for its binding affinity against sigma 1 opioid receptor using 3[H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109387(3-Methyl-1-(3-phenyl-propyl)-piperidine | CHEMBL14...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109386(2-Phenethyl-1,2,3,4-tetrahydro-isoquinoline | CHEM...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109390(2-(3-Phenyl-propyl)-1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataKi:  14nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50008585(4-Methyl-1-phenethyl-piperidine | CHEMBL343237)
Affinity DataKi:  21nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109383(1-(3-Phenyl-propyl)-4-pyridin-2-yl-piperazine | 1-...)
Affinity DataKi:  83nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109389(1-Phenethyl-piperidine | 1-phenethylpiperidine | C...)
Affinity DataKi:  89nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109391(1-(3-Phenyl-propyl)-piperidine | CHEMBL148108)
Affinity DataKi:  143nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50109388(1-(2-phenylethyl)-4-(2-pyridyl)piperazine | 1-Phen...)
Affinity DataKi:  326nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115286(CHEMBL3609016)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115227(CHEMBL3609018)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50095732(2-[2-({2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-...)
Affinity DataIC50:  5.40nMAssay Description:Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115227(CHEMBL3609018)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50095735(2-[2-({2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-...)
Affinity DataIC50:  11.8nMAssay Description:Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50095731(2-[2-({2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-...)
Affinity DataIC50:  12.4nMAssay Description:Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione S-transferase A1(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186225(3-((3-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phen...)
Affinity DataIC50:  13.7nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150948(US8981106, 137)
Affinity DataIC50:  14nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM362182(USRE47267, Compound 137)
Affinity DataIC50:  14nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione S-transferase A1(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186230(3-((4-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phen...)
Affinity DataIC50:  14.3nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150905(US8981106, 94)
Affinity DataIC50:  16nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  21nMAssay Description:Inhibition of CXCR2 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115286(CHEMBL3609016)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  22nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  22nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutathione S-transferase A1(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186229(3,5-bis((2-(2-(2,3-dichloro-4-(2-methylenebutanoyl...)
Affinity DataIC50:  24nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150824(US8981106, 14 (SX-585) | USRE47267, Compound 14)
Affinity DataIC50:  28nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150824(US8981106, 14 (SX-585) | USRE47267, Compound 14)
Affinity DataIC50:  28nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  31nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione S-transferase P(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186227(3-((8-(2-(2,3-dichloro-4-(1-hydroxy-2-methylenebut...)
Affinity DataIC50:  31nMAssay Description:Inhibition of GST P1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM362193(USRE47267, Compound 168)
Affinity DataIC50:  32nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150979(US8981106, 168)
Affinity DataIC50:  32nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutathione S-transferase A1(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186228(3,5-bis((2-(2,3-dichloro-4-(2-methylenebutanoyl)ph...)
Affinity DataIC50:  32.7nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50095733(2-[2-(2-{2-[2-Dibenzylamino-3-(4-hydroxy-phenyl)-p...)
Affinity DataIC50:  35nMAssay Description:Binding affinity against Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150975(US8981106, 165 | USRE47267, Compound 165)
Affinity DataIC50:  37nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150975(US8981106, 165 | USRE47267, Compound 165)
Affinity DataIC50:  37nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  38nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutathione S-transferase A1(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186223(3-((7-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phen...)
Affinity DataIC50:  39.3nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione S-transferase P(Homo sapiens (Human))
Syntrix Biosytems

Curated by ChEMBL
LigandPNGBDBM50186223(3-((7-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phen...)
Affinity DataIC50:  46.1nMAssay Description:Inhibition of GST P1-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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