TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Maryland
Curated by ChEMBL
University Of Maryland
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Compound was tested for its binding affinity against sigma 1 opioid receptor using 3[H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Maryland
Curated by ChEMBL
University Of Maryland
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Compound was tested for its binding affinity against sigma 1 opioid receptor using 3[H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Maryland
Curated by ChEMBL
University Of Maryland
Curated by ChEMBL
Affinity DataKi: 4.90nMAssay Description:Compound was tested for its binding affinity against sigma 1 opioid receptor using 3[H]-(+)-pentazocine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 5.90nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 83nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 89nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 143nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataKi: 326nMAssay Description:Binding affinity of the compound for sigma-1 receptor by displacing [3H]-(+) pentazocineMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 11.8nMAssay Description:Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataIC50: 12.4nMAssay Description:Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataIC50: 13.7nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
Affinity DataIC50: 14nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 14.3nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
Affinity DataIC50: 16nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of CXCR2 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
Affinity DataIC50: 28nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of GST P1-1More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 32.7nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Binding affinity against Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataIC50: 37nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMT: 2°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 39.3nMAssay Description:Inhibition of GST A1-1More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
Affinity DataIC50: 46.1nMAssay Description:Inhibition of GST P1-1More data for this Ligand-Target Pair